Creager Mark A, Matsushita Kunihiro, Arya Shipra, Beckman Joshua A, Duval Sue, Goodney Philip P, Gutierrez J Antonio T, Kaufman John A, Joynt Maddox Karen E, Pollak Amy W, Pradhan Aruna D, Whitsel Laurie P
Circulation. 2021 Apr 27;143(17):e875-e891. doi: 10.1161/CIR.0000000000000967. Epub 2021 Mar 25.
Nontraumatic lower-extremity amputation is a devastating complication of peripheral artery disease (PAD) with a high mortality and medical expenditure. There are ≈150 000 nontraumatic leg amputations every year in the United States, and most cases occur in patients with diabetes. Among patients with diabetes, after an ≈40% decline between 2000 and 2009, the amputation rate increased by 50% from 2009 to 2015. A number of evidence-based diagnostic and therapeutic approaches for PAD can reduce amputation risk. However, their implementation and adherence are suboptimal. Some racial/ethnic groups have an elevated risk of PAD but less access to high-quality vascular care, leading to increased rates of amputation. To stop, and indeed reverse, the increasing trends of amputation, actionable policies that will reduce the incidence of critical limb ischemia and enhance delivery of optimal care are needed. This statement describes the impact of amputation on patients and society, summarizes medical approaches to identify PAD and prevent its progression, and proposes policy solutions to prevent limb amputation. Among the actions recommended are improving public awareness of PAD and greater use of effective PAD management strategies (eg, smoking cessation, use of statins, and foot monitoring/care in patients with diabetes). To facilitate the implementation of these recommendations, we propose several regulatory/legislative and organizational/institutional policies such as adoption of quality measures for PAD care; affordable prevention, diagnosis, and management; regulation of tobacco products; clinical decision support for PAD care; professional education; and dedicated funding opportunities to support PAD research. If these recommendations and proposed policies are implemented, we should be able to achieve the goal of reducing the rate of nontraumatic lower-extremity amputations by 20% by 2030.
非创伤性下肢截肢是外周动脉疾病(PAD)的一种严重并发症,死亡率高且医疗费用高昂。在美国,每年约有15万例非创伤性腿部截肢病例,大多数病例发生在糖尿病患者中。在糖尿病患者中,截肢率在2000年至2009年间下降了约40%,但从2009年到2015年又上升了50%。一些基于证据的PAD诊断和治疗方法可以降低截肢风险。然而,这些方法的实施和依从性并不理想。一些种族/族裔群体患PAD的风险较高,但获得高质量血管护理的机会较少,导致截肢率上升。为了阻止并切实扭转截肢率上升的趋势,需要制定可行的政策,以降低严重肢体缺血的发生率,并加强提供最佳护理。本声明描述了截肢对患者和社会的影响,总结了识别PAD并预防其进展的医学方法,并提出了预防肢体截肢的政策解决方案。建议采取的行动包括提高公众对PAD的认识,以及更多地使用有效的PAD管理策略(如戒烟、使用他汀类药物以及对糖尿病患者进行足部监测/护理)。为了促进这些建议的实施,我们提出了几项监管/立法和组织/机构政策,如采用PAD护理质量指标;提供可负担的预防、诊断和管理;对烟草产品进行监管;为PAD护理提供临床决策支持;专业教育;以及提供专门的资金机会以支持PAD研究。如果这些建议和提议的政策得以实施,我们应该能够实现到2030年将非创伤性下肢截肢率降低20%的目标。