Kaser Susanne, Radlinger Bernhard, Blasinger Jana, Koellenberger Nicolas, Streitberger Verena, Kopp Lena, Bifano Elena, Aziz Faisal, Sourij Harald, Goebel Georg, Klocker Josef
Department for Internal Medicine I, Medical University Innsbruck, 6020 Innsbruck, Austria.
Department of Vascular Surgery, Medical University of Innsbruck, 6020 Innsbruck, Austria.
J Clin Med. 2025 Jun 6;14(12):4030. doi: 10.3390/jcm14124030.
Non-traumatic lower-limb amputations are associated with high mortality and a dramatic loss of quality of life. Peripheral artery disease and diabetes are the most common causes of non-traumatic lower-limb amputations. The aim of the study was to assess temporal trends in mortality, comorbidities and sex differences in patients with non-traumatic lower-limb amputations. : A total of 1107 patients who underwent lower-limb amputation for non-traumatic causes at the Medical University of Innsbruck between 2006 and 2022 were reviewed and analyzed. Temporal trends in mortality, sex-differences in outcomes and the comorbidity spectrum were assessed. : In hospitals, 30-day and 1-year mortality has remained high from 2006 to 2022 (4.14%; 16.2%; 23.2%) with chronic kidney disease, heart failure and major amputations as predictors of 1-year mortality. Diabetes, peripheral artery disease and cerebrovascular disease were the most common causes of death in females, and liver disease, renal disease and myocardial infarction in males, respectively. Overall comorbidity frequency was high, with there being even increasing rates of coronary heart disease, atrial fibrillation and chronic pulmonary disease during the study period. Age at first amputation was significantly higher in women than in men (78.9 vs. 68.1 years). Median age increased and median LDL-cholesterol decreased in males but not in females during the time period. Major amputations were performed more frequently in females than in males as the first surgical intervention. : Mortality and morbidity are high in patients with non-traumatic limb amputation. Our data underline the need of intensified risk-factor management with lower limb amputation, especially in females.
非创伤性下肢截肢与高死亡率和生活质量的显著下降相关。外周动脉疾病和糖尿病是非创伤性下肢截肢最常见的原因。本研究的目的是评估非创伤性下肢截肢患者的死亡率、合并症及性别差异的时间趋势。：回顾并分析了2006年至2022年间在因斯布鲁克医科大学因非创伤性原因接受下肢截肢的1107例患者。评估了死亡率的时间趋势、结局的性别差异以及合并症谱。：在医院中，2006年至2022年期间30天和1年死亡率一直居高不下（分别为4.14%、16.2%、23.2%），慢性肾病、心力衰竭和大截肢是1年死亡率的预测因素。糖尿病、外周动脉疾病和脑血管疾病分别是女性最常见的死亡原因，而男性为肝病、肾病和心肌梗死。总体合并症发生率较高，在研究期间冠心病、心房颤动和慢性肺病的发生率甚至呈上升趋势。女性首次截肢的年龄显著高于男性（78.9岁对68.1岁）。在此期间，男性的年龄中位数增加，低密度脂蛋白胆固醇中位数下降，而女性则没有。作为首次手术干预，女性比男性更频繁地进行大截肢。：非创伤性肢体截肢患者的死亡率和发病率较高。我们的数据强调了对下肢截肢患者加强危险因素管理的必要性，尤其是在女性患者中。
