Wang Ming-Liang, Yu Meng-Meng, Li Wen-Bin, Li Yue-Hua
Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233,China.
Curr Alzheimer Res. 2021;18(1):8-13. doi: 10.2174/1567205018666210324125116.
White matter (WM) beta-amyloid uptake has been used as a reference region to calculate the cortical standard uptake value ratio (SUVr). However, white matter hyperintensities (WMH) may have an influence on WM beta-amyloid uptake. Our study aimed to investigate the associations between WMH and WM beta-amyloid deposition in cognitively unimpaired elderly.
Data from 83 cognitively unimpaired individuals in the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset were analyzed. All participants had complete baseline and four-year follow-up information about WMH volume, WM 18F-AV-45 SUVr, and cognitive function, including ADNI-Memory (ADNI-Mem) and ADNI-Executive function (ADNI-EF) scores. Cross-sectional and longitudinal linear regression analyses were used to determine the associations between WMH and WM SUVr and cognitive measures.
Lower WM 18F-AV-45 SUVr at baseline was associated with younger age (β=0.01, P=0.037) and larger WMH volume (β=-0.049, P=0.048). The longitudinal analysis found an annual increase in WM 18F-AV-45 SUVr was associated with an annual decrease in WMH volume (β=-0.016, P=0.041). An annual decrease in the ADNI-Mem score was associated with an annual increase in WMH volume (β=-0.070, P=0.001), an annual decrease in WM 18F-AV-45 SUVr (β=0.559, P=0.030), and fewer years of education (β=0.011, P=0.044). There was no significant association between WM 18F-AV-45 SUVr and ADNI-EF (P>0.05).
Reduced beta-amyloid deposition in WM was associated with higher WMH load and memory decline in cognitively unimpaired elderly. WMH volume should be considered when WM 18F-AV-45 SUVr is used as a reference for evaluating cortical 18F-AV-45 SUVr.
白质（WM）β-淀粉样蛋白摄取已被用作计算皮质标准摄取值比率（SUVr）的参考区域。然而，白质高信号（WMH）可能会对白质β-淀粉样蛋白摄取产生影响。我们的研究旨在调查认知未受损老年人中WMH与白质β-淀粉样蛋白沉积之间的关联。
对阿尔茨海默病神经影像倡议（ADNI）数据集中83名认知未受损个体的数据进行分析。所有参与者均有关于WMH体积、白质18F-AV-45 SUVr以及认知功能（包括ADNI-记忆（ADNI-Mem）和ADNI-执行功能（ADNI-EF）评分）的完整基线和四年随访信息。采用横断面和纵向线性回归分析来确定WMH与白质SUVr以及认知指标之间的关联。
基线时较低的白质18F-AV-45 SUVr与较年轻的年龄（β=0.01，P=0.037）和较大的WMH体积（β=-0.049，P=0.048）相关。纵向分析发现，白质18F-AV-45 SUVr的年度增加与WMH体积的年度减少相关（β=-0.016，P=0.041）。ADNI-Mem评分的年度降低与WMH体积的年度增加（β=-0.070，P=0.001）、白质18F-AV-45 SUVr的年度降低（β=0.559，P=0.030）以及受教育年限减少（β=0.011，P=0.044）相关。白质18F-AV-45 SUVr与ADNI-EF之间无显著关联（P>0.05）。
认知未受损老年人中，白质β-淀粉样蛋白沉积减少与较高的WMH负荷和记忆衰退相关。当将白质18F-AV-45 SUVr用作评估皮质18F-AV-45 SUVr的参考时，应考虑WMH体积。
