从主观记忆障碍到遗忘型轻度认知障碍的白质网络破坏
Disrupted White Matter Networks from Subjective Memory Impairment to Amnestic Mild Cognitive Impairment.
作者信息
Shao Wen, He Xuwen, Li Xin, Tao Wuhai, Zhang Junying, Zhang Shujuan, Wang Lei, Qiao Yanan, Wang Yu, Zhang Zhanjun, Peng Dantao
机构信息
Department of Neurology, China-Japan Friendship Hospital, Beijing 100029,China.
State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875,China.
出版信息
Curr Alzheimer Res. 2021;18(1):35-44. doi: 10.2174/1567205018666210324115817.
BACKGROUND AND OBJECTIVE
Subjective memory impairment (SMI) is a preclinical stage prior to amnestic mild cognitive impairment (aMCI) along with the Alzheimer's disease (AD) continuum. We hypothesized that SMI patients had white matter (WM) network disruptions similar to those in aMCI patients.
METHODS
We used diffusion-tensor magnetic resonance imaging and graph theory to construct, analyze, and compare the WM networks among 20 normal controls (NC), 20 SMI patients, and 20 aMCI patients.
RESULTS
Compared with the NC group, the SMI group had significantly decreased global and local efficiency and an increased shortest path length. Moreover, similar to the aMCI group, the SMI group had lower nodal efficiency in regions located in the frontal and parietal lobes, limbic systems, and caudate nucleus compared to that of the NC group.
CONCLUSION
Similar to aMCI patient, SMI patients exhibited WM network disruptions, and detection of these disruptions could facilitate the early detection of SMI.
背景与目的
主观记忆障碍（SMI）是遗忘型轻度认知障碍（aMCI）之前的一个临床前期阶段，属于阿尔茨海默病（AD）连续谱。我们假设SMI患者存在与aMCI患者相似的白质（WM）网络破坏。
方法
我们使用扩散张量磁共振成像和图论来构建、分析和比较20名正常对照（NC）、20名SMI患者和20名aMCI患者的WM网络。
结果
与NC组相比，SMI组的全局和局部效率显著降低，最短路径长度增加。此外，与aMCI组相似，与NC组相比，SMI组在额叶、顶叶、边缘系统和尾状核区域的节点效率较低。
结论
与aMCI患者相似，SMI患者表现出WM网络破坏，检测这些破坏可能有助于SMI的早期发现。
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