Zheng Qinfang, Wang Ye, Zhang Shuihan
Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
Key Laboratory of Dong Medical Research of Hunan Province, Hunan University of Medicine, Huaihua, China.
Front Pharmacol. 2021 Mar 8;12:638210. doi: 10.3389/fphar.2021.638210. eCollection 2021.
In this work, we reviewed the progress in the phytochemical and biological investigations of bioactive components derived from medicinally valuable species. In the last 60 years, has garnered significant attention from the phytochemist from around the world, majorly due to the discovery of bioactive piperidine alkaloids (e.g., lobinaline and lobeline) in the early 1950s. Later, lobeline underwent clinical trials for several indications including the treatment of attention deficit hyperactivity disorder and a multicenter phase three trial for smoking cessation. Subsequently, several other alkaloids derived from different species of were also investigated for their pharmacological characteristics. However, in the last few years, the research focus has started shifting to the characterization of the other novel chemical classes. The major shift has been noticed due to the structurally similar alkaloid components, which essentially share similar pharmacological, physicochemical, and toxicological profiles. In this review, we present an up-to-date overview of their progress with special attention to understanding the molecular mechanisms of the novel bioactive components.
在这项工作中，我们回顾了从具有药用价值的物种中提取的生物活性成分的植物化学和生物学研究进展。在过去的60年里，它受到了世界各地植物化学家的极大关注，主要是由于在20世纪50年代初发现了生物活性哌啶生物碱（如洛贝林和去甲洛贝林）。后来，洛贝林针对包括注意力缺陷多动障碍治疗在内的多种适应症进行了临床试验，并针对戒烟进行了多中心三期试验。随后，还对从不同物种中提取的其他几种生物碱的药理特性进行了研究。然而，在过去几年中，研究重点已开始转向其他新型化学类别的表征。由于结构相似的生物碱成分，主要转变已经显现，这些成分基本上具有相似的药理、物理化学和毒理学特征。在这篇综述中，我们特别关注了解新型生物活性成分的分子机制，对其进展进行了最新概述。
