Komatsu Hiroshi, Takeuchi Hikaru, Ono Chiaki, Yu Zhiqian, Kikuchi Yoshie, Kakuto Yoshihisa, Funakoshi Shunichi, Ono Takashi, Kawashima Ryuta, Taki Yasuyuki, Tomita Hiroaki
Department of Psychiatry, Tohoku University Hospital, Sendai, Japan.
Miyagi Psychiatric Center, Natori, Japan.
Front Psychiatry. 2021 Mar 8;12:631475. doi: 10.3389/fpsyt.2021.631475. eCollection 2021.
Recent evidence has indicated that the disruption of oligodendrocytes may be involved in the pathogenesis of depression. Genetic factors are likely to affect trait factors, such as characteristics, rather than state factors, such as depressive symptoms. Previously, a negative self-schema had been proposed as the major characteristic of constructing trait factors underlying susceptibility to depression. Thus, the association between a negative self-schema and the functional single nucleotide polymorphism (SNP) rs1059004 in the gene, which influences gene expression, white matter integrity, and cerebral blood flow, was evaluated. A total of 546 healthy subjects were subjected to genotype and psychological evaluation using the Beck Depression Inventory-II (BDI-II) and the Brief Core Schema Scale (BCSS). The rs1059004 SNP was found to be associated with the self-schema subscales of the BCSS and scores on the BDI-II in an allele dose-dependent manner, and to have a predictive impact on depressive symptoms via a negative-self schema. The results suggest the involvement of a genetic factor regulating oligodendrocyte function in generating a negative-self schema as a trait factor underlying susceptibility to depression.
最近的证据表明，少突胶质细胞的破坏可能参与了抑郁症的发病机制。遗传因素可能影响特质因素，如性格特征，而非状态因素，如抑郁症状。此前，消极自我图式被认为是构建抑郁症易感性潜在特质因素的主要特征。因此，研究人员评估了消极自我图式与基因中功能性单核苷酸多态性（SNP）rs1059004之间的关联，该基因影响基因表达、白质完整性和脑血流量。共有546名健康受试者接受了基因分型，并使用贝克抑郁量表第二版（BDI-II）和简要核心图式量表（BCSS）进行了心理评估。研究发现，rs1059004 SNP与BCSS的自我图式子量表及BDI-II得分呈等位基因剂量依赖性相关，并通过消极自我图式对抑郁症状产生预测作用。结果表明，调节少突胶质细胞功能的遗传因素参与了消极自我图式的形成，而消极自我图式是抑郁症易感性的潜在特质因素。
