Cao Tingting, Xie Bing, Yang Siyuan, Wang Jiaqi, Yang Xiao, Shen Boqiang, Lin Xueke, Sun Xiuli, Wang Jianliu
Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing, China.
The Key Laboratory of Female Pelvic Floor Disorders Disease of Peking University, Beijing, China.
Front Med (Lausanne). 2021 Mar 8;8:572846. doi: 10.3389/fmed.2021.572846. eCollection 2021.
Acute urinary retention (AUR) is a troublesome urological disease, which causes various lower urinary tract symptoms. However, only few studies explored and evaluated the effective treatments to improve AUR. We aimed to find an effective approach to cure AUR through comparing the efficacy of existing classical low-frequency transcutaneous electrical nerve stimulation (TENS) and novel intravesical electrical stimulation (IVES). A total of 24 AUR female rats were divided into 3 groups as follows: control, TENS, and IVES groups. Rats in the control group had no fake stimulation. Rats in the TENS and IVES groups underwent transcutaneous or intravesical stimulation of a symmetrical biphasic rectangular current pulse with a frequency of 35 Hz, 30 min per day, for seven consecutive days. IVES significantly reduced the actin expression in the submucosal layer but increased its expression in the detrusor layer ( = 0.035, = 0.001). The neovascularization in the submucosal layer in the IVES group was significantly increased than in the other 2 groups ( = 0.006). Low-frequency IVES performed better than TENS in terms of simultaneously relieving bladder hyperactivity, accelerating epithelial recovery, and strengthening detrusor muscle. IVES may be a promising therapeutic approach for bladder dysfunction, specifically for AUR and overactive bladder in clinical practice.
急性尿潴留（AUR）是一种棘手的泌尿系统疾病，会引发各种下尿路症状。然而，仅有少数研究探索和评估了改善AUR的有效治疗方法。我们旨在通过比较现有的经典低频经皮电神经刺激（TENS）和新型膀胱内电刺激（IVES）的疗效，找到一种治愈AUR的有效方法。总共24只患AUR的雌性大鼠被分为以下3组：对照组、TENS组和IVES组。对照组大鼠不接受假刺激。TENS组和IVES组的大鼠接受频率为35Hz的对称双相矩形电流脉冲的经皮或膀胱内刺激，每天30分钟，连续7天。IVES显著降低了黏膜下层肌动蛋白的表达，但增加了逼尿肌层中肌动蛋白的表达（P = 0.035，P = 0.001）。IVES组黏膜下层的新生血管形成明显多于其他两组（P = 0.006）。在同时缓解膀胱过度活动、加速上皮恢复和增强逼尿肌方面，低频IVES比TENS表现更好。IVES可能是治疗膀胱功能障碍的一种有前景的治疗方法，特别是在临床实践中治疗AUR和膀胱过度活动症。
