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基于纳米技术的策略来评估和对抗癌症转移和新生血管形成。

Nanotechnology-Based Strategies to Evaluate and Counteract Cancer Metastasis and Neoangiogenesis.

机构信息

Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, Pontedera, Pisa, 56025, Italy.

Sabanci University Nanotechnology Research and Application Center (SUNUM), Sabanci University, Universite Caddesi 27-1, Tuzla, Istanbul, 34956, Turkey.

出版信息

Adv Healthc Mater. 2021 May;10(10):e2002163. doi: 10.1002/adhm.202002163. Epub 2021 Mar 24.

DOI:10.1002/adhm.202002163
PMID:33763992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7610913/
Abstract

Cancer metastasis is the major cause of cancer-related morbidity and mortality. It represents one of the greatest challenges in cancer therapy, both because of the ability of metastatic cells to spread into different organs, and because of the consequent heterogeneity that characterizes primary and metastatic tumors. Nanomaterials can potentially be used as targeting or detection agents owing to unique chemical and physical features that allow tailored and tunable theranostic functions. This review highlights nanomaterial-based approaches in the detection and treatment of cancer metastasis, with a special focus on the evaluation of nanostructure effects on cell migration, invasion, and angiogenesis in the tumor microenvironment.

摘要

癌症转移是癌症相关发病率和死亡率的主要原因。它是癌症治疗中最大的挑战之一，不仅因为转移细胞有扩散到不同器官的能力，还因为原发性和转移性肿瘤的异质性。纳米材料由于其独特的化学和物理特性，具有可定制和可调谐的治疗功能，因此有可能被用作靶向或检测试剂。本综述重点介绍了基于纳米材料的癌症转移检测和治疗方法，特别关注了纳米结构对肿瘤微环境中细胞迁移、侵袭和血管生成的影响评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/d1f2df8b035b/ADHM-10-2002163-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/26aaf7592e42/ADHM-10-2002163-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/231a14f6e38a/ADHM-10-2002163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/642e393f7c41/ADHM-10-2002163-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/527640be1614/ADHM-10-2002163-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/451146ae4447/ADHM-10-2002163-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/6aac578edccf/ADHM-10-2002163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/07ddcb737092/ADHM-10-2002163-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/d1f2df8b035b/ADHM-10-2002163-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/26aaf7592e42/ADHM-10-2002163-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/97e7038552ee/ADHM-10-2002163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/231a14f6e38a/ADHM-10-2002163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/642e393f7c41/ADHM-10-2002163-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/527640be1614/ADHM-10-2002163-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/451146ae4447/ADHM-10-2002163-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/6aac578edccf/ADHM-10-2002163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/07ddcb737092/ADHM-10-2002163-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/487f/11469149/d1f2df8b035b/ADHM-10-2002163-g008.jpg

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3
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ACS Appl Mater Interfaces. 2023 Jun 28;15(25):30008-30028. doi: 10.1021/acsami.3c07248. Epub 2023 Jun 13.
4
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