3,4-二氢嘧啶-2-硫酮与芳基醇的氧化脱氢碳氧交叉偶联反应。
Oxidative Dehydrosulfurative Carbon-Oxygen Cross-Coupling of 3,4-Dihydropyrimidine-2-thiones with Aryl Alcohols.
机构信息
Department of Chemistry, Chungnam National University, Daejeon 34134, Republic of Korea.
Yonsung Fine Chemicals R&D Center, Suwon 16675, Republic of Korea.
出版信息
J Org Chem. 2021 Apr 2;86(7):5423-5430. doi: 10.1021/acs.joc.1c00273. Epub 2021 Mar 25.
PMID:33764055
Abstract
A Pd-catalyzed/Cu-mediated oxidative dehydrosulfurative carbon-oxygen cross-coupling reaction of 3,4-dihydropyrimidin-1-2-thiones (DHPMs) with aryl alcohols is described. Due to the ready availability of diverse DHPMs and aryl alcohols, the reaction method offers facile access to biologically and pharmacologically valuable 2-aryloxypyrimidine derivatives with rapid diversification.
摘要
Pd 催化/Cu 介导的 3,4-二氢嘧啶-1,2-硫酮（DHPMs）与芳醇的氧化去硫醇化碳-氧交叉偶联反应被描述。由于各种 DHPMs 和芳醇的易得性，该反应方法为具有快速多样化的生物和药理学价值的 2-芳氧基嘧啶衍生物提供了简便的途径。
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