Department of Anesthesiology, Pain Management & Perioperative Medicine- Henry Ford Health System, Detroit, MI, USA.
Lakeside Spine & Pain, Lake Havasu City, AZ, USA.
Pain Manag. 2021 Apr;11(4):419-431. doi: 10.2217/pmt-2020-0052. Epub 2021 Mar 25.
Knee osteoarthritis is a degenerative joint disease that is secondary to degradation of articular cartilage, reformation of subchondral bone through degradation and proliferation as well as presence of synovitis. This systematic review was conducted and reported as per Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. A total of 30 of the 48 comparators showed statistically significant superiority with platelet-rich plasma (PRP) compared with a control, while the other 16 comparators showed no significant difference between PRP and the comparator. We can only recommend PRP for patients with early-stage osteoarthritis (I or II) and who are aged below 65, based on our findings. Based on the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) recommendations, while studies reviewed were randomized controlled studies, and therefore, high grade, due to variance in imprecision, risk of bias and inconsistency among the 37 studies, it would be reasonable to rate this paper as subjectively moderate.
膝骨关节炎是一种退行性关节疾病，继发于关节软骨降解、软骨下骨通过降解和增殖以及滑膜炎的重建。本系统评价是按照系统评价和荟萃分析报告的首选报告项目进行的。48 个对照物中有 30 个与富血小板血浆（PRP）相比具有统计学上的优越性，而另外 16 个对照物在 PRP 和对照物之间没有显著差异。根据我们的发现，我们只能建议将 PRP 用于早期骨关节炎（I 或 II 期）和 65 岁以下的患者。根据推荐评估、制定和评估（GRADE）建议，虽然所审查的研究是随机对照研究，因此是高级别，由于 37 项研究中存在不精确性、偏倚风险和不一致性的差异，因此将这篇论文主观评为中度是合理的。
