经典型先天性肾上腺皮质增生症患者的生物电阻抗相位角及其决定因素。

Bioelectrical Impedance Phase Angle and Its Determinants in Patients with Classic Congenital Adrenal Hyperplasia.

机构信息

Laboratory of Growth and Development (LabCreD) - Center for Investigation in Pediatrics (CIPED) - School of Medical Sciences (FCM), State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

出版信息

J Am Nutr Assoc. 2022 May-Jun;41(4):407-414. doi: 10.1080/07315724.2021.1895902. Epub 2021 Mar 25.

DOI:10.1080/07315724.2021.1895902

PMID:33764276

Abstract

BACKGROUND

Patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH21OHD) have increased fat mass and metabolic alterations. The bioelectrical impedance phase angle (PhA) is an indicator of cellular integrity in several diseases. This study aimed to determine the influence of adiposity levels, sex, CAH21OHD, pubertal development, body composition, and treatment on the PhA of patients with CAH21OHD.

METHODS

Forty girls and 30 boys with CAH21OHD aged 15.3 ± 5.8 years were evaluated. Sexual maturation was assessed by a pediatrician. The PhA was assessed using bioelectrical impedance, percentage of fat mass (% FM), and lean soft tissue (LST) with dual-energy X-ray absorptiometry. Adiposity levels were compared using % FM tertiles and body mass index (BMI). Glucocorticoid dosage was converted using hydrocortisone dose equivalent (HDE).

RESULTS

No differences were found in the PhA values among the clinical form ( = 0.103), BMI ( = 0.498), and % FM ( = 0.654) groups. High PhA values were observed in boys ( = 0.011) and postpubertal ( < 0.001) patients. LST, HDE, and height in girls (r = 0.68, < 0.001) and age, HDE, and FM in boys (r = 0.82, < 0.001) determined the PhA variations. BMI explained 14% ( = 0.032) of the PhA variations, whereas LST, height, HDE, and FM (kg) explained 66% ( < 0.001) in the prepubertal, pubertal, and postpubertal groups, respectively.

CONCLUSION

LST determined the PhA variations in girls and the postpubertal group. Age and BMI were determinants in boys and the pre- and pubertal groups, respectively.

摘要

背景

患有 21-羟化酶缺乏症（CAH21OHD）的先天性肾上腺皮质增生症患者体脂增加且代谢异常。生物电阻抗相位角（PhA）是多种疾病细胞完整性的一个指标。本研究旨在确定体脂水平、性别、CAH21OHD、青春期发育、身体成分和治疗对 CAH21OHD 患者 PhA 的影响。

方法

评估了 40 名女孩和 30 名男孩，年龄 15.3±5.8 岁，均患有 CAH21OHD。儿科医生评估了性成熟度。使用生物电阻抗法评估 PhA，使用双能 X 射线吸收法评估体脂百分比（% FM）和瘦软组织（LST）。使用 FM 三分位数和体重指数（BMI）比较体脂水平。使用氢化可的松剂量等效值（HDE）转换糖皮质激素剂量。

结果

临床表型（=0.103）、BMI（=0.498）和% FM（=0.654）组之间的 PhA 值无差异。男孩（=0.011）和青春期后（<0.001）患者的 PhA 值较高。女孩的 LST、HDE 和身高（r=0.68，<0.001）以及男孩的年龄、HDE 和 FM（r=0.82，<0.001）与 PhA 变化有关。BMI 解释了 PhA 变化的 14%（=0.032），而 LST、身高、HDE 和 FM（kg）分别解释了青春期前、青春期和青春期后组的 66%（<0.001）。