Hasanzamani Boshra, Karimi Nasrin, Sabbagh Mahin Ghorban, Majd Hasan Mahrad
1Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Kidney Dis. 2021 Mar;15(2):148-154.
Pre-transplant serum phosphorus level is shown to be associated with some transplant outcomes in patients with chronic kidney disease. However, its association with Delayed graft function (DGF) has an aura of ambiguity. DGF means either the patient needs dialysis during the first week after transplantation or the creatinine level is ≥ 3. This study was aimed to assess the relationship between pre-transplant serum phosphorus levels with DGF.
A total of 306 patients, who had undergone kidney transplantation in the Montaserieh organ transplantation hospital in Mashhad, Iran, during 2016 to 2019; were enrolled in this study. Demographic data and clinical characteristics of patients including dialysis type and duration, donor type, medications, pre-transplant serum levels of calcium, phosphorus and DGF development were measured. Then, all patients were divided into five groups according to their serum phosphorus: P < 3.5, 3.5 ≤ P < 5.5, 5.5 ≤ P < 7.5, 7.5 ≤ P < 9.5, and P ≥ 9.5 mg/dL. The association with DGF was evaluated by statistical analysis.
Patients age ranged from 18.00 to 64.00 years old, with an average of 37.08 ± 10.9. About 55.6% of them were men, and 26.1% came up with DGF. Among patients with DGF, 36.25% were recipients with pre-transplant phosphorus level of 3.5 ≤ P < 5.5 and 50% of 5.5 ≤ P < 7.5.
Our study suggested that pre-transplant serum phosphorus might be associated with an increased risk of delayed graft function. Further studies are needed to assess, whether adjusting serum phosphorus level before kidney transplantation could reduce delayed graft function or not.
慢性肾病患者移植前血清磷水平与某些移植结局相关。然而，其与移植肾功能延迟恢复（DGF）的关联尚存在一定的不确定性。DGF是指患者在移植后第一周内需要透析，或者肌酐水平≥3。本研究旨在评估移植前血清磷水平与DGF之间的关系。
选取2016年至2019年期间在伊朗马什哈德蒙塔泽里耶器官移植医院接受肾移植的306例患者纳入本研究。测量患者的人口统计学数据和临床特征，包括透析类型和时长、供体类型、用药情况、移植前血清钙、磷水平以及DGF的发生情况。然后，根据血清磷水平将所有患者分为五组：P<3.5、3.5≤P<5.5、5.5≤P<7.5、7.5≤P<9.5以及P≥9.5mg/dL。通过统计分析评估与DGF的关联。
患者年龄在18.00至64.00岁之间，平均年龄为37.08±10.9岁。其中约55.6%为男性，26.1%发生了DGF。在发生DGF的患者中，36.25%是移植前磷水平为3.5≤P<5.5的受者，50%是5.5≤P<7.5的受者。
我们的研究表明，移植前血清磷可能与移植肾功能延迟恢复风险增加有关。需要进一步研究评估肾移植前调整血清磷水平是否可以降低移植肾功能延迟恢复的发生。
