Am J Vet Res. 2021 Apr;82(4):261-267. doi: 10.2460/ajvr.82.4.261.
To determine the cardiopulmonary effects of IV administration of fentanyl to cats anesthetized with isoflurane and during anesthetic recovery with concurrent administration of acepromazine or dexmedetomidine.
6 healthy adult cats.
Cats received an IV bolus (5 μg/kg) followed by an IV infusion (5 μg/kg/h) of fentanyl for 120 minutes during isoflurane anesthesia and for 30 minutes after discontinuing isoflurane. Cats were randomly assigned in a crossover study to receive acepromazine (0.05 mg/kg) or dexmedetomidine (2.5 μg/kg), IV, when isoflurane was discontinued. Cardiopulmonary data were obtained during anesthesia and for 30 minutes during the anesthetic recovery period.
The administration of fentanyl during isoflurane anesthesia resulted in a transient increase in arterial blood pressure, mean pulmonary artery pressure, and oxygen delivery. Compared with values during isoflurane anesthesia, administration of dexmedetomidine during anesthetic recovery resulted in significant decreases in cardiac index, stroke index, and oxygen delivery and significant increases in arterial, central venous, and mean pulmonary artery pressures; systemic vascular resistance index; and oxygen extraction ratio. Administration of acepromazine resulted in increases in heart rate, cardiac index, oxygen uptake, and oxygen extraction ratio. Oxygen extraction ratio did not differ between acepromazine and dexmedetomidine.
Fentanyl transiently improved indices of cardiopulmonary performance when administered to healthy cats anesthetized with isoflurane. The cardiovascular effects of acepromazine and dexmedetomidine in healthy cats receiving fentanyl during recovery from isoflurane anesthesia differed, but measured cardiopulmonary parameters remained within acceptable limits.
确定静脉注射芬太尼对异氟醚麻醉的猫的心肺影响，并在同时给予乙酰丙嗪或右美托咪定麻醉恢复期间。
6 只健康成年猫。
猫接受静脉推注（5μg/kg），然后静脉输注（5μg/kg/h）芬太尼 120 分钟，在异氟醚麻醉期间和异氟醚停止后 30 分钟。猫在交叉研究中随机接受静脉注射乙酰丙嗪（0.05mg/kg）或右美托咪定（2.5μg/kg），当异氟醚停止时。在麻醉期间和麻醉恢复期间的 30 分钟内获得心肺数据。
在异氟醚麻醉期间给予芬太尼导致动脉血压、肺动脉平均压和氧输送短暂增加。与异氟醚麻醉期间的值相比，在麻醉恢复期间给予右美托咪定导致心指数、搏出指数和氧输送显著降低，而动脉压、中心静脉压和肺动脉平均压显著升高；全身血管阻力指数；和氧摄取率。给予乙酰丙嗪导致心率、心指数、摄氧量和氧摄取率增加。乙酰丙嗪和右美托咪定的氧摄取率没有差异。
芬太尼在健康猫接受异氟醚麻醉时短暂改善心肺功能指标。在接受芬太尼恢复期间接受乙酰丙嗪和右美托咪定的健康猫中，心血管作用不同，但测量的心肺参数仍在可接受范围内。
