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急性内科住院患者的高钠血症处理不充分。

Suboptimal management of hypernatraemia in acute medical admissions.

机构信息

Department of Geriatric Medicine, Saolta University Health Care Group (SUHCG), University Hospital Galway, Galway, Ireland.

School of Mathematics, Statistics and Applied Mathematics, National University of Ireland Galway, Galway, Ireland.

出版信息

Age Ageing. 2021 May 5;50(3):990-995. doi: 10.1093/ageing/afab056.

Abstract

BACKGROUND

Hypernatraemia arises commonly in acute general medical admissions. Affected patients have a guarded prognosis with high rates of morbidity and mortality. Age-related physiology and physical/cognitive barriers to accessing water predispose older patients to developing hypernatraemia. This study sought to perform a descriptive retrospective review of hypernatraemic patients admitted under acute general medicine teams.

METHODS

A retrospective cross-sectional study of a sample of acute medical in-patients with serum[sodium]>145 mmol/L was conducted. Patients were exclusively older(>69 years) and admitted from Nursing homes (NH)(41%) and non-NH pathways(59%). A comparison of management of NH /non-NH patients including clinical presentation, comorbidities, laboratory values, [sodium] monitoring, intravenous fluid regimes and patient outcomes was performed.

RESULTS

In total, 102 consecutive patients (males, n=69(67.6%)) were included. Dementia and reduced mobility were more common in NH residents and admission serum [Sodium] higher (148 vs 142 mmol/L/p=0.003). Monitoring was inadequate: no routine bloods within the first 12h in >80% of patients in both groups. No patient had calculated free water deficit documented. More NH patients received correct fluid management (60% vs 33%/p%0.015). Incorrect fluid regimes occurred in both groups (38% vs 58%/p=0.070). Length of stay in discharged patients was lower in NH, (8(4-20) vs 20.5(9.8-49.3 days)/p=0.003). Time to death for NH residents was shorter (9(5.5-11.5) vs 16 (10.25-23.5) days/p=0.011).

CONCLUSION

This study highlights suboptimal management of hypernatraemia. Implementation of hypernatraemia guidelines for general medical older inpatients are clearly required with mechanisms to confirm adherence. Health care workers require further education on diagnostic challenges of dehydration in older people and the importance of maintaining adequate hydration.

摘要

背景

高钠血症在急性综合医学入院中很常见。受影响的患者预后不佳,发病率和死亡率都很高。与年龄相关的生理和获取水的身体/认知障碍使老年患者更容易发生高钠血症。本研究旨在对急性内科综合医疗团队收治的高钠血症患者进行描述性回顾性分析。

方法

对血清[sodium]>145mmol/L 的急性内科住院患者进行回顾性横断面研究。患者均为老年人(>69 岁),分别来自养老院(NH)(41%)和非 NH 途径(59%)。对 NH/非 NH 患者的管理进行比较,包括临床表现、合并症、实验室值、[sodium]监测、静脉补液方案和患者结局。

结果

共纳入 102 例连续患者(男性,n=69(67.6%))。NH 居民更常见痴呆和活动能力下降,入院时血清[sodium]更高(148 与 142mmol/L/p=0.003)。监测不足:两组患者>80%在最初 12 小时内均未常规查血。没有患者的游离水不足有记录。NH 患者接受正确的液体管理的比例更高(60%与 33%/p%0.015)。两组均出现错误的液体方案(38%与 58%/p=0.070)。NH 出院患者的住院时间更短(8(4-20)与 20.5(9.8-49.3 天)/p=0.003)。NH 居民的死亡时间更短(9(5.5-11.5)与 16(10.25-23.5)天/p=0.011)。

结论

本研究强调了高钠血症管理的不足。明确需要为老年综合内科住院患者制定高钠血症指南,并建立机制来确认遵守情况。医疗保健工作者需要进一步接受关于老年人脱水的诊断挑战以及保持充足水合作用的重要性的教育。

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