Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata, 700054, India.
Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata, 700054, India.
Carbohydr Res. 2021 Apr;502:108294. doi: 10.1016/j.carres.2021.108294. Epub 2021 Mar 16.
An efficient synthetic strategy has been developed for the synthesis of the sialic acid containing pentasaccharide repeating unit of the cell wall O-antigen of Streptococcus group B type VI strain involving stereoselective α-glycosylation of sialic acid thioglycoside derivative. Stereoselective glycosylation of glycosyl trichloroacetimidate derivatives and thioglycosides were carried out using perchloric acid supported over silica (HClO-SiO) as a solid acid catalyst. A panel of sialic acid donors has been screened for achieving satisfactory yield and stereochemical outcome of the glycosylation reaction.
现已开发出一种有效的合成策略，用于合成 B 族链球菌 VI 型菌株细胞壁 O-抗原的含唾液酸五糖重复单元，该策略涉及唾液酸硫糖苷衍生物的立体选择性α-糖苷化。使用负载在二氧化硅上的高氯酸（HClO-SiO）作为固体酸催化剂，对糖基三氯乙酰亚胺酯衍生物和硫糖苷进行立体选择性糖苷化。已经筛选了一系列唾液酸供体，以实现糖苷化反应的令人满意的产率和立体化学结果。
