Shit Pradip, Misra Anup Kumar
Division of Molecular Medicine, Bose Institute, P-1/12, C.I.T. Scheme VII M, Kolkata, 700054, India.
Glycoconj J. 2020 Oct;37(5):647-656. doi: 10.1007/s10719-020-09933-z. Epub 2020 Jun 29.
A concise synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the cell wall O-antigen of Escherichia coli O43 strain involving stereoselective β-D-mannosylation and α-L-fucosylation using corresponding trichloroacetimidate intermediates and perchloric acid supported over silica (HClO-SiO) as glycosylation promoter. The yield and stereoselectivity of the glycosylations were very good.
已开发出一种简洁的合成策略，用于合成大肠杆菌O43菌株细胞壁O抗原的五糖重复单元，该策略涉及使用相应的三氯乙酰亚胺酯中间体以及负载在硅胶上的高氯酸（HClO - SiO）作为糖基化促进剂进行立体选择性β - D - 甘露糖基化和α - L - 岩藻糖基化。糖基化反应的产率和立体选择性都非常好。
