Gilinskiĭ M A
Zh Vyssh Nerv Deiat Im I P Pavlova. 1988 Jan-Feb;38(1):89-93.
It is shown that disturbance of conditioned reaction of passive avoidance in Wistar rats, elicited after bilateral amygdalectomy, may be compensated by administration of indirect dopamine agonist--methylphenidate. Two-fold administration proved to be effective: that before learning and that before testing. Two-fold administration of another dopamine agonist--amantadine did not restore the disturbed conditioned reaction. The results are discussed in the aspect of the role of different dopamine brain systems in passive avoidance and possible specificity of the drugs action.
结果表明，双侧杏仁核切除术后Wistar大鼠被动回避条件反应的紊乱，可通过给予间接多巴胺激动剂——哌甲酯得到补偿。两次给药被证明是有效的：一次在学习前，一次在测试前。另一种多巴胺激动剂——金刚烷胺的两次给药未能恢复紊乱的条件反应。从不同多巴胺脑系统在被动回避中的作用以及药物作用可能的特异性方面对结果进行了讨论。
