Gene polymorphisms associated with an increased risk of exudative age-related macular degeneration in a Spanish population.

PURPOSE

To identify the association between single-nucleotide polymorphisms (SNPs) in , and genes and exudative age-related macular degeneration (AMD) in a Spanish population.

METHODS

In 187 exudative AMD patients and 196 healthy controls (61% women, mean age 75 years), 12 SNPs as risk factors for AMD in (rs1410996, rs1061170, r380390), ARMS2 (rs10490924, rs10490923), (rs11200638), (rs641153), (rs547154, rs9332739), and (rs147859257, rs2230199, rs1047286) genes were analyzed.

RESULTS

The G allele was the most frequent in CFH gene (rs1410996) with a 7-fold increased risk of AMD (OR 7.69, 95% CI 3.17-18.69), whereas carriers of C allele in (rs1061170) showed a 3-fold increased risk for AMD (OR 3.22, 95% CI 1.93-5.40). In (rs380390), the presence of G allele increased the risk for AMD by 2-fold (OR 2.52, 95% CI 1.47-4.30). In (rs10490924), the T-allele was associated with an almost 5-fold increased risk (OR 5.49, 95% CI 3.23-9.31). The A allele in (rs11200638) was more prevalent in AMD versus controls (OR 6.44, 95% CI 3.62-11.47). In gene (rs9332739) the presence of C increased risk for AMD by 3-fold (OR 3.10, 95% CI 1.06-9.06).

CONCLUSION

SNPs in , and genes were associated in our study with an increased risk for exudative AMD in Spanish patients.