Zavalishin I A, Pogodina V V, Roikhel' V M, Fokina G I, Niiazbekova A S
Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(2):11-6.
Twenty-six patients including 12 with lateral amyotrophic sclerosis, 7 with multiple sclerosis, 5 with the Creutzfeld-Jakob disease and 2 with Alzheimer's disease were examined. Antibodies to neurofilaments in the blood serum were detected in all cases of the Creutzfeld-Jakob disease and Alzheimer's disease and in 8 patients with lateral amyotrophic sclerosis with clinical evidence of supranuclear structure involvement. A conclusion is drawn about a certain similarity of pathogenic mechanisms of these diseases, as well as about heterogeneity of the cytoskeleton of neurons in the brain and the spinal cord.
对26例患者进行了检查，其中包括12例侧索肌萎缩症患者、7例多发性硬化症患者、5例克雅氏病患者和2例阿尔茨海默病患者。在所有克雅氏病和阿尔茨海默病病例以及8例有核上结构受累临床证据的侧索肌萎缩症患者中，均检测出血清中的神经丝抗体。得出了关于这些疾病致病机制存在一定相似性以及脑和脊髓中神经元细胞骨架存在异质性的结论。
