Master's and Doctoral Program in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno 475, CEP: 03071-000, Tatuapé, São Paulo SP, Brazil.
Master's and Doctoral Program in Physical Therapy, Universidade Cidade de São Paulo, Rua Cesário Galeno 475, CEP: 03071-000, Tatuapé, São Paulo SP, Brazil.
Braz J Phys Ther. 2021 Sep-Oct;25(5):573-582. doi: 10.1016/j.bjpt.2021.02.006. Epub 2021 Mar 9.
Cost-utility analysis uses utility indexes to assess treatment effects. Some discrepancies between different utility indexes instruments are suggested and need to be identified in health conditions not yet investigated.
To compare different utility indexes instruments in Brazilian patients with fibromyalgia and identify variables associated with these instruments.
Impact of fibromyalgia (Fibromyalgia Impact Questionnaire [FIQ]) and utility indexes (Short-Form 6 Dimensions [SF-6D], EuroQol 5 Dimensions [EQ-5D], and EuroQol - Visual Analogue Scale [EQ-VAS]) were assessed in 97 patients with fibromyalgia at baseline, 8-week (after an exercise-based intervention), and 6- and 12-month follow-up. Construct validity and responsiveness of the utility indexes instruments were compared. Multiple regression models were used to verify the variables associated with the utility indexes instruments.
Construct validity analysis showed that FIQ presented moderate correlation with the SF-6D, the EQ-5D, and the EQ-VAS (r=-0.43, -0.41, -0.30, respectively, all p < .01). There was a moderate correlation between the SF-6D and the EQ-5D (r = 0.51, p < .001), moderate correlation between the SF-6D and the EQ-VAS (r = 0.41, p < .001), and no correlation between the EQ-VAS and the EQ-5D. The EQ-5D was responsive at the 8-week and 6-month follow-up, the SF-6D was responsive only at 6-month follow-up and the EQ-VAS was not responsive. The FIQ was associated with the EQ-5D and the SF-6D indexes, and symptom duration and depression with the EQ-VAS index.
The EQ-5D better assessed the clinical change in patients with fibromyalgia. Furthermore, impact of fibromyalgia, symptom duration, and depression seem to be associated with the utility indexes.
成本效用分析使用效用指数来评估治疗效果。一些不同的效用指数工具之间存在差异，需要在尚未研究的健康状况中确定。
比较巴西纤维肌痛患者的不同效用指数工具，并确定与这些工具相关的变量。
在基线、8 周（基于运动的干预后）以及 6 个月和 12 个月随访时，评估 97 例纤维肌痛患者的纤维肌痛影响（纤维肌痛影响问卷 [FIQ]）和效用指数（简短 6 维度 [SF-6D]、欧洲五维健康量表 [EQ-5D]和欧洲五维健康量表视觉模拟量表 [EQ-VAS]）。比较了效用指数工具的结构有效性和反应性。使用多元回归模型来验证与效用指数工具相关的变量。
结构有效性分析表明，FIQ 与 SF-6D、EQ-5D 和 EQ-VAS 呈中度相关（r=-0.43、-0.41、-0.30，均 p<0.01）。SF-6D 与 EQ-5D 中度相关（r=0.51，p<0.001），SF-6D 与 EQ-VAS 中度相关（r=0.41，p<0.001），EQ-VAS 与 EQ-5D 无相关性。EQ-5D 在 8 周和 6 个月随访时具有反应性，SF-6D 仅在 6 个月随访时具有反应性，而 EQ-VAS 不具有反应性。FIQ 与 EQ-5D 和 SF-6D 指数相关，症状持续时间和抑郁与 EQ-VAS 指数相关。
EQ-5D 更好地评估了纤维肌痛患者的临床变化。此外，纤维肌痛的影响、症状持续时间和抑郁似乎与效用指数相关。
