Department of Chemistry, Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India.
Department of Biotechnology, Guru Nanak Dev University, Amritsar 143005, India.
Bioorg Med Chem Lett. 2021 Jun 1;41:127982. doi: 10.1016/j.bmcl.2021.127982. Epub 2021 Mar 23.
Design and synthesis of new indole derivatives as tumor growth inhibiting agents via inhibiting the TNF-α is described. The preliminary results showed the inhibition of LPS induced production of NO, TNF-α and IL-6 by these compounds out of which compounds 2d and 2g exhibited appreciable cytotoxicity against the 60 cell lines panel of human cancer. The rationale behind the design of the molecules and the results of their biological studies are presented. 2009 Elsevier Ltd. All rights reserved.
本文描述了通过抑制 TNF-α 来设计和合成新型吲哚衍生物作为肿瘤生长抑制剂。初步结果表明，这些化合物抑制 LPS 诱导的 NO、TNF-α 和 IL-6 的产生，其中化合物 2d 和 2g 对人癌细胞 60 细胞系面板表现出明显的细胞毒性。介绍了分子设计的原理和生物研究结果。 2009 年爱思唯尔有限公司版权所有。
