Krinke G, Froehlich E, Herrmann M, Schnider K, Da Silva F, Suter J, Traber K
Ciba-Geigy AG, Basel, Switzerland.
Acta Anat (Basel). 1988;131(3):182-7. doi: 10.1159/000146510.
Atrophy of the L4 dorsal and ventral spinal roots was experimentally induced by unilateral sciatic neurectomy in groups of young (2 and 4 months) and older (12 months) albino rats. During the 4 months following neurectomy, the occurrence of infolded myelin loops (IMLs) was quantitatively examined in transverse sections prepared using perfusion fixation with glutaraldehyde and embedding in epoxy resin. The number of IMLs was higher on the operated side and increased with the time of survival and the age of the animals. The formation of IMLs is a characteristic early response of a large-caliber myelin sheath to axonal atrophy, probably reflecting the presence of redundant myelin.
通过对年轻（2个月和4个月）及年长（12个月）白化大鼠进行单侧坐骨神经切除术，实验性诱导L4背侧和腹侧脊髓神经根萎缩。在神经切除术后的4个月里，使用戊二醛灌注固定并包埋于环氧树脂中制备横切面，对折叠髓鞘环（IML）的出现情况进行定量检查。手术侧的IML数量更多，且随着存活时间和动物年龄的增加而增多。IML的形成是大口径髓鞘对轴突萎缩的一种典型早期反应，可能反映了多余髓鞘的存在。
