Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA.
Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
Br J Cancer. 2021 Jul;125(1):4-6. doi: 10.1038/s41416-021-01360-7. Epub 2021 Mar 25.
Classification of cancer should lead to informative patients' stratification and selective therapeutic vulnerabilities. A pathway-based classification of glioblastoma uncovered a mitochondrial subtype with a unique sensitivity to inhibitors of oxidative phosphorylation. Precision targeting of cancer metabolism could provide therapeutic opportunities to a lethal neoplasm and be translated to other tumour types.
癌症的分类应该能够为患者提供有意义的分层，并针对治疗的弱点进行选择。基于通路的胶质母细胞瘤分类揭示了一种具有独特氧化磷酸化抑制剂敏感性的线粒体亚型。对癌症代谢的精确靶向可能为致命肿瘤提供治疗机会，并可转化为其他肿瘤类型。
