Bäckman E, Bengtsson A, Bengtsson M, Lennmarken C, Henriksson K G
Department of Neurophysiology, University Hospital, Linköping, Sweden.
Acta Neurol Scand. 1988 Mar;77(3):187-91. doi: 10.1111/j.1600-0404.1988.tb05893.x.
Muscle fatigue is the most disabling symptom in primary fibromyalgia (PF), which in addition is characterized by generalised pain and muscle stiffness. In order to assess whether the fatigue is of central and/or peripheral origin, skeletal muscle function was studied by measuring maximum voluntary hand grip strength, and by measuring various contraction characteristics in the adductor pollicis muscle after electrical stimulation of the ulnar nerve. The PF-patients were also studied after a regional sympathetic blockade of the forearm with guanethidine. A lower hand grip strength was found in the PF-patients compared to the controls, before as well as during the sympathetic blockade. The developed force, measured during electrical stimulation, did not differ between patients and controls. A lower muscle relaxation rate was found in the PF-patients. The relaxation rate increased in the PF-patients during the sympathetic blockade. The results indicate both a central and a peripheral cause of muscle dysfunction. Activity in the muscle sympathetic system may be one link in the chain of events that leads to muscular symptoms in PF.
肌肉疲劳是原发性纤维肌痛（PF）中最致残的症状，此外，原发性纤维肌痛还具有全身疼痛和肌肉僵硬的特征。为了评估疲劳是中枢性和/或外周性起源，通过测量最大自主握力以及在尺神经电刺激后测量拇收肌的各种收缩特征来研究骨骼肌功能。在用胍乙啶对前臂进行局部交感神经阻滞后，也对PF患者进行了研究。与对照组相比，在交感神经阻滞之前和期间，PF患者的握力较低。在电刺激期间测量的发力在患者和对照组之间没有差异。在PF患者中发现肌肉放松速率较低。在交感神经阻滞期间，PF患者的放松速率增加。结果表明肌肉功能障碍有中枢性和外周性原因。肌肉交感神经系统的活动可能是导致PF肌肉症状的一系列事件中的一个环节。
