治疗性血浆置换：韦格纳肉芽肿病中的一种救命疗法。
Therapeutic plasma exchange: A life-saving modality in Wegener's granulomatosis.
作者信息
Solanki Archana, Singh Ashutosh, Chauhan Abhishek, Chandra Tulika, Himanshu D
机构信息
Department of Transfusion Medicine, KGMU, Lucknow, Uttar Pradesh, India.
Department of Radiodiagnosis, Dr. RML institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
出版信息
Asian J Transfus Sci. 2020 Jul-Dec;14(2):203-205. doi: 10.4103/ajts.AJTS_89_19. Epub 2020 Dec 19.
We report a case of Wegener's granulomatosis (WG) who very well responded to the combination strategy of therapeutic plasma exchange (TPE) and immunosuppression. The patient was a 38-year-old female, diagnosed with severe form of WG. A total of seven cycles was performed with 1.3 total plasma volumes (TPVs) on every alternate day. Standard induction therapy was also started that comprised of a combination of 500 mg intravenous (i.v.) cyclophosphamide and methylprednisolone 1 g slow i.v. daily for 3 days followed by oral prednisolone 60 mg daily for 4 weeks. After seven cycles of TPE, the patient improved and hence TPE was stopped.
我们报告一例韦格纳肉芽肿（WG）患者，其对治疗性血浆置换（TPE）与免疫抑制的联合策略反应良好。该患者为一名38岁女性，被诊断为重症韦格纳肉芽肿。共进行了七个周期的治疗，每隔一天置换1.3个总血浆量（TPV）。同时开始标准诱导治疗，包括静脉注射500mg环磷酰胺和每天静脉缓慢注射1g甲泼尼龙，持续3天，随后口服泼尼松龙60mg，持续4周。经过七个周期的TPE治疗后，患者病情改善，因此停止了TPE治疗。
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