运动即良药：运动训练对非酒精性脂肪性肝病的影响。
Exercise as Medicine: The Impact of Exercise Training on Nonalcoholic Fatty Liver Disease.
作者信息
Thorp Audrey, Stine Jonathan G
机构信息
Department of Medicine, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey PA, USA.
Division of Gastroenterology and Hepatology, Department of Medicine, The Pennsylvania State University- Milton S. Hershey Medical Center, Hershey PA, USA.
出版信息
Curr Hepatol Rep. 2020 Dec;19(4):402-411. doi: 10.1007/s11901-020-00543-9. Epub 2020 Sep 9.
Abstract
PURPOSE OF REVIEW
Nonalcoholic fatty liver disease (NAFLD) is a leading cause of global liver disease. Because current pharmacologic treatments are ineffective, lifestyle change centered on exercise remains the most effective NAFLD treatment. The aim of this systematic review is to summarize and evaluate the current evidence supporting the use of exercise training as a medical treatment for adult patients with NAFLD.
RECENT FINDINGS
At least 150 minutes each week of moderate intensity exercise of any type can improve NAFLD, both with and without modest weight loss. Exercise training reduces hepatic steatosis and liver inflammation, favorably changes body composition, improves vascular endothelial function, increases cardiorespiratory fitness and can lead to histologic response. To date, exercise-based NAFLD trials are limited by small sample size and significant heterogeneity.
SUMMARY
While several key questions remain unanswered, exercise training will always be an important part of the medical management of patients with NAFLD.
摘要
综述目的
非酒精性脂肪性肝病（NAFLD）是全球肝脏疾病的主要病因。由于目前的药物治疗无效，以运动为核心的生活方式改变仍然是NAFLD最有效的治疗方法。本系统综述的目的是总结和评估目前支持将运动训练作为成年NAFLD患者医学治疗方法的证据。
最新发现
每周至少进行150分钟的任何类型的中等强度运动，无论是否伴有适度体重减轻，均可改善NAFLD。运动训练可减少肝脏脂肪变性和肝脏炎症，有益地改变身体成分，改善血管内皮功能，提高心肺适能，并可导致组织学反应。迄今为止，基于运动的NAFLD试验受到样本量小和显著异质性的限制。
总结
虽然几个关键问题仍未得到解答，但运动训练将始终是NAFLD患者医学管理的重要组成部分。
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