Kichloo Asim, Albosta Michael, Dahiya Dushyant, Guidi Jean Claude, Aljadah Michael, Singh Jagmeet, Shaka Hafeez, Wani Farah, Kumar Akshay, Lekkala Manidhar
Department of Internal Medicine, Central Michigan University, Saginaw, MI 48603, United States.
Department of Internal Medicine, Samaritan Medical Center, Watertown, NY 13601, United States.
World J Clin Oncol. 2021 Mar 24;12(3):150-163. doi: 10.5306/wjco.v12.i3.150.
Immunotherapy is rapidly evolving secondary to the advent of newer immunotherapeutic agents and increasing approval of the current agents by the United States Food and Drug Administration to treat a wide spectrum of cancers. Immunotherapeutic agents have gained immense popularity due to their tumor-specific action. Immunotherapy is slowly transforming into a separate therapeutic entity, and the fifth pillar of management for cancers alongside surgery, radiotherapy, chemotherapy, and targeted therapy. However, like any therapeutic entity it has its own adverse effects. With the increasing use of immuno-therapeutic agents, it is vital for physicians to acquaint themselves with these adverse effects. The aim of this review is to investigate the common systemic adverse effects and toxicities associated with the use of different classes of immunotherapeutic agents. We provide an overview of potential adverse effects and toxicities associated with different classes of immunotherapeutic agents organized by organ systems, as well as an extensive discussion of the current recommendations for treatment and clinical trial data. As we continue to see increasing usage of these agents in clinical practice, it is vital for physicians to familiarize themselves with these effects.
随着更新的免疫治疗药物的出现以及美国食品药品监督管理局对现有药物治疗多种癌症的批准日益增多，免疫疗法正在迅速发展。免疫治疗药物因其肿瘤特异性作用而广受欢迎。免疫疗法正逐渐转变为一种独立的治疗手段，成为继手术、放疗、化疗和靶向治疗之后癌症治疗的第五大支柱。然而，与任何治疗手段一样，它也有自身的不良反应。随着免疫治疗药物使用的增加，医生了解这些不良反应至关重要。本综述的目的是研究与使用不同类别的免疫治疗药物相关的常见全身不良反应和毒性。我们按器官系统概述了与不同类别的免疫治疗药物相关的潜在不良反应和毒性，并对当前的治疗建议和临床试验数据进行了广泛讨论。随着我们在临床实践中不断看到这些药物的使用增加，医生熟悉这些效应至关重要。
