Ghafouri-Fard Soudeh, Abak Atefe, Mohaqiq Mahdi, Shoorei Hamed, Taheri Mohammad
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Front Cell Dev Biol. 2021 Mar 9;9:634512. doi: 10.3389/fcell.2021.634512. eCollection 2021.
The insulin-like growth factors (IGFs) are polypeptides with similar sequences with insulin. These factors regulate cell growth, development, maturation, and aging via different processes including the interplay with MAPK, Akt, and PI3K. IGF signaling participates in the pathogenesis of neoplasia, insulin resistance, diabetes mellitus, polycystic ovarian syndrome, cerebral ischemic injury, fatty liver disease, and several other conditions. Recent investigations have demonstrated the interplay between non-coding RNAs and IGF signaling. This interplay has fundamental roles in the development of the mentioned disorders. We designed the current study to search the available data about the role of IGF-associated non-coding RNAs in the evolution of neoplasia and other conditions. As novel therapeutic strategies have been designed for modification of IGF signaling, identification of the impact of non-coding RNAs in this pathway is necessary for the prediction of response to these modalities.
胰岛素样生长因子（IGFs）是与胰岛素序列相似的多肽。这些因子通过包括与丝裂原活化蛋白激酶（MAPK）、蛋白激酶B（Akt）和磷脂酰肌醇-3-激酶（PI3K）相互作用在内的不同过程来调节细胞生长、发育、成熟和衰老。IGF信号传导参与肿瘤形成、胰岛素抵抗、糖尿病、多囊卵巢综合征、脑缺血损伤、脂肪性肝病及其他多种病症的发病机制。最近的研究表明非编码RNA与IGF信号传导之间存在相互作用。这种相互作用在上述疾病的发展中具有重要作用。我们开展本研究旨在搜索有关IGF相关非编码RNA在肿瘤形成及其他病症演变中作用的现有数据。由于已设计出针对IGF信号传导修饰的新型治疗策略，因此确定非编码RNA在该途径中的影响对于预测对这些治疗方式的反应是必要的。
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