Pan Yuxia, Xu Li, Yang Xinchun, Chen Mulei, Gao Yuanfeng
Heart Center & Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Heart Fail Rev. 2022 May;27(3):837-847. doi: 10.1007/s10741-021-10095-9. Epub 2021 Mar 25.
Atrial fibrillation (AF) and heart failure (HF) are common chronic diseases noted in humans. AF and HF share several risk factors, such as age, hypertension, obesity, diabetes, and dyslipidemia. They can interact with each other, while both their morbidity and mortality have been considerably increased. And AF and HF often occur together, suggesting a strong association between the two. However, the underlying mechanism behind this association is not well understood. Among them, aging is the most significant common risk factor, which represents an aging heart and is characterized by fibrosis and decreased number of cardiomyocytes, known as senescence-related cardiac remodeling for both atria and ventricles. Finally, it is proposed that cardiac remodeling is the key link between AF and HF.
心房颤动（AF）和心力衰竭（HF）是人类常见的慢性疾病。AF和HF有几个共同的危险因素，如年龄、高血压、肥胖、糖尿病和血脂异常。它们会相互影响，导致发病率和死亡率显著增加。而且AF和HF常常同时发生，表明两者之间存在密切关联。然而，这种关联背后的潜在机制尚不清楚。其中，衰老 是最显著的共同危险因素，它表现为心脏老化，特征是纤维化和心肌细胞数量减少，即心房和心室的衰老相关心脏重塑。最后，有人提出心脏重塑是AF和HF之间的关键环节。
