Wiklund Olov
professor emeri-tus, institutionen för medicin, Sahlgrenska akademin, Göteborgs universitet.
Lakartidningen. 2021 Mar 24;118:20216.
In two recent publications LDL-cholesterol and cardiovascular risk in the elderly was studied. A study from Copenhagen shows that LDL-cholesterol is similar as a risk-factor for myocardial infarction in all age-groups. Due to the higher incidence of myocardial infarction with age, the number of events associated with an increased LDL is higher among the elderly. The effect of LDL reduction in the elderly was studied in a meta-analysis including statin studies as well as studies with ezetimibe and PCSK9 inhibitors. The relative risk reduction associated with a reduction of 1 mmol/l of LDL-cholesterol was 26%, similar for patients above or below 75 years of age. These studies emphasize that reduction of LDL should be considered also in the elderly without many comorbidities.
在最近的两篇出版物中，对老年人的低密度脂蛋白胆固醇（LDL - 胆固醇）与心血管风险进行了研究。哥本哈根的一项研究表明，LDL - 胆固醇作为心肌梗死的风险因素在所有年龄组中相似。由于心肌梗死的发病率随年龄增长而升高，老年人中与LDL升高相关的事件数量更多。在一项荟萃分析中研究了老年人降低LDL的效果，该荟萃分析包括他汀类药物研究以及依泽替米贝和前蛋白转化酶枯草溶菌素9（PCSK9）抑制剂的研究。LDL - 胆固醇每降低1 mmol/L相关的相对风险降低为26%，75岁以上或以下的患者相似。这些研究强调，对于没有很多合并症的老年人也应考虑降低LDL。
