机械通气 COVID-19 患者肺部 CCR6+CD8+T 细胞和 CCL20 的富集。
Enrichment of CCR6 CD8 T cells and CCL20 in the lungs of mechanically ventilated patients with COVID-19.
机构信息
Center for Experimental and Molecular Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
Department of Clinical Chemistry, Medical Immunology Laboratory, Amsterdam UMC, Amsterdam, The Netherlands.
出版信息
Eur J Immunol. 2021 Jun;51(6):1535-1538. doi: 10.1002/eji.202049046. Epub 2021 May 11.
Abstract
Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3 cells but rather CCR6 , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. .
摘要
尽管机械通气的 COVID-19 患者的 CXCR3 配体水平较高，但 BALF CD8 T 细胞并未富集 CXCR3 细胞，而是 CCR6，这可能是由于 BALF 中 CCL20 水平较高，并且 PD-1 表达水平非常高。在机械通气的患者中，但不在病房患者中，Th-1 免疫受损。
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