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妊娠期首诊获得性血栓性血小板减少性紫癜,经血浆置换和利妥昔单抗治疗后预后良好:一例报告

Acquired thrombotic thrombocytopenic Purpura diagnosed during first trimester of pregnancy with excellent outcome after plasma exchange and rituximab, a case report.

作者信息

Arzuaga-Mendez Javier, Moreno Maite, Mateos-Mazón Juan J, Vara Miriam, Dueñas Marta, Del Orbe Rafael A, Amutio Elena, Arrizabalaga Beatriz, García-Ruiz Juan C

机构信息

Hematology and Hemotherapy Service Cruces University Hospital Biocruces Bizkaia Health Research Institute Barakaldo Bizkaia Spain.

出版信息

Clin Case Rep. 2021 Feb 2;9(3):1304-1306. doi: 10.1002/ccr3.3752. eCollection 2021 Mar.

DOI:10.1002/ccr3.3752
PMID:33768832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7981779/
Abstract

Acquired thrombotic thrombocytopenic purpura is a life-threatening condition that rarely presents during pregnancy. Early diagnosis and treatment with plasma exchange is needed to achieve a good pregnancy outcome.

摘要

获得性血栓性血小板减少性紫癜是一种危及生命的疾病,在孕期很少出现。需要早期诊断并进行血浆置换治疗,以获得良好的妊娠结局。

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Thrombotic thrombocytopenic purpura during pregnancy versus imitator of preeclampsia.妊娠期血栓性血小板减少性紫癜与子痫前期的模仿者
Transfusion. 2015 Oct;55(10):2516-8. doi: 10.1111/trf.13207. Epub 2015 Aug 10.
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Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura and other thrombotic microangiopathies.血栓性血小板减少性紫癜及其他血栓性微血管病的诊断与管理指南
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A phase 2 study of the safety and efficacy of rituximab with plasma exchange in acute acquired thrombotic thrombocytopenic purpura.一项评估利妥昔单抗联合血浆置换治疗急性获得性血栓性血小板减少性紫癜的安全性和有效性的 2 期研究。
Blood. 2011 Aug 18;118(7):1746-53. doi: 10.1182/blood-2011-03-341131. Epub 2011 Jun 2.
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