NTRK2融合驱动的儿童胶质母细胞瘤：通过综合基因组和转录组分析鉴定致癌驱动因素
NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling.
作者信息
Britton Heidi M, Levine Adrian B, Shen Yaoqing, Mungall Karen, Serrano Jonathan, Snuderl Matija, Pleasance Erin, Jones Steven J M, Laskin Janessa, Marra Marco A, Rassekh Shahrad R, Deyell Rebecca, Yip Stephen, Cheng Sylvia, Dunham Chris
机构信息
Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada.
Canada's Michael Smith Genome Sciences Centre British Columbia Cancer Agency Vancouver Canada.
出版信息
Clin Case Rep. 2021 Feb 10;9(3):1472-1477. doi: 10.1002/ccr3.3804. eCollection 2021 Mar.
This is the first report of a NACC2-NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care.
这是关于组织学胶质母细胞瘤中NACC2-NTRK2融合的首次报告。肿瘤基因组分析在一例儿童小脑胶质母细胞瘤中发现了这种可靶向治疗的融合致癌基因，而通过常规诊断无法识别该基因，这证明了临床基因组分析在癌症治疗中的价值。
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