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S-1对苯巴比妥和苯妥英血药浓度的影响：一例报告

Effect of S-1 on blood levels of phenobarbital and phenytoin: A case report.

作者信息

Shiraiwa Ken, Ono Hiroyuki, Tanaka Ryota, Fujinaga Atsuro, Hiratsuka Takahiro, Tatsuta Ryosuke, Inomata Masafumi, Itoh Hiroki

机构信息

Department of Clinical Pharmacy Oita University Hospital, Yufu-shi Oita Japan.

Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine, Yufu-shi Oita Japan.

出版信息

Clin Case Rep. 2021 Feb 4;9(3):1514-1517. doi: 10.1002/ccr3.3813. eCollection 2021 Mar.

DOI:10.1002/ccr3.3813
PMID:33768879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7981613/
Abstract

Drug-drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S-1 (tegafur/gimeracil/oteracil) and radiation therapy for rectal cancer.

摘要

氟嘧啶类抗癌药与苯妥英之间的药物相互作用已广为人知，但与苯巴比妥的相互作用却很有限。我们描述了一例在直肠癌术前接受S-1（替加氟/吉美嘧啶/奥替拉西）和放射治疗期间血浆苯巴比妥以及苯妥英浓度升高的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bed6/7981613/dfa300dfb8eb/CCR3-9-1514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bed6/7981613/dfa300dfb8eb/CCR3-9-1514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bed6/7981613/dfa300dfb8eb/CCR3-9-1514-g002.jpg

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本文引用的文献

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2
A prospective feasibility study to evaluate neoadjuvant-synchronous S-1 with radiotherapy for locally advanced rectal cancer: A multicentre phase II trial.一项评估新辅助同步S-1联合放疗治疗局部晚期直肠癌的前瞻性可行性研究：一项多中心II期试验。
Mol Clin Oncol. 2016 Apr;4(4):510-514. doi: 10.3892/mco.2016.767. Epub 2016 Feb 4.
3
Variations in the Blood Phenytoin Levels during Long-Term Combined Treatment with S-1 and Phenytoin.
S-1与苯妥英钠长期联合治疗期间血液中苯妥英水平的变化。
Case Rep Oncol. 2014 Sep 26;7(3):656-61. doi: 10.1159/000368077. eCollection 2014 Sep-Dec.
4
Sequential interaction of phenytoin and phenobarbital with fluorouracil.苯妥英钠和苯巴比妥与氟尿嘧啶的序贯相互作用。
Int J Clin Pharmacol Ther. 2012 Dec;50(12):862-6. doi: 10.5414/CP201677.
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Biomarkers for antiepileptic drug response.抗癫痫药物反应的生物标志物。
Biomark Med. 2011 Oct;5(5):635-41. doi: 10.2217/bmm.11.75.
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Gan To Kagaku Ryoho. 2011 Jun;38(6):1003-6.
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