S-1对苯巴比妥和苯妥英血药浓度的影响：一例报告
Effect of S-1 on blood levels of phenobarbital and phenytoin: A case report.
作者信息
Shiraiwa Ken, Ono Hiroyuki, Tanaka Ryota, Fujinaga Atsuro, Hiratsuka Takahiro, Tatsuta Ryosuke, Inomata Masafumi, Itoh Hiroki
机构信息
Department of Clinical Pharmacy Oita University Hospital, Yufu-shi Oita Japan.
Department of Gastroenterological and Pediatric Surgery Oita University Faculty of Medicine, Yufu-shi Oita Japan.
出版信息
Clin Case Rep. 2021 Feb 4;9(3):1514-1517. doi: 10.1002/ccr3.3813. eCollection 2021 Mar.
Drug-drug interaction of fluorinated pyrimidine anticancer agents with phenytoin is well known, but interaction with phenobarbital is limited. We describe a case showing increases in plasma phenobarbital as well as phenytoin concentrations during preoperative S-1 (tegafur/gimeracil/oteracil) and radiation therapy for rectal cancer.
氟嘧啶类抗癌药与苯妥英之间的药物相互作用已广为人知，但与苯巴比妥的相互作用却很有限。我们描述了一例在直肠癌术前接受S-1（替加氟/吉美嘧啶/奥替拉西）和放射治疗期间血浆苯巴比妥以及苯妥英浓度升高的病例。
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