Yenigün Bülent Mustafa, Kahya Yusuf, Soydal Çiğdem, Ata Tutkun Nihal, Kocaman Gökhan, Koçak Emre Muhammed, Özkan Elgin, Dizbay Sak Serpil, Kayı Cangır Ayten
Department of Thoracic Surgery, Ankara University School of Medicine, Ankara, Turkey.
Department of Nuclear Medicine, Ankara University School of Medicine, Ankara, Turkey.
Turk Gogus Kalp Damar Cerrahisi Derg. 2021 Jan 13;29(1):92-100. doi: 10.5606/tgkdc.dergisi.2021.20432. eCollection 2021 Jan.
In this study, we aimed to investigate the prognostic value of metabolic F-fluorodeoxyglucose positron emission tomography/computed tomography parameters in malignant pleural mesothelioma patients.
A total of 65 patients with malignant pleural mesothelioma (34 males, 31 females; median age: 60 years; range, 39 to 84 years) who underwent whole-body F-fluorodeoxyglucose positron emission tomography/computed tomography for staging before treatment between March 2008 and January 2018 were included. Relationships between clinicopathological factors and F-fluorodeoxyglucose positron emission tomography/computed tomography parameters and overall survival were evaluated using a log-rank test and Cox regression analysis.
The median follow-up was 13 (range, 4 to 55) months. The Kaplan-Meier analysis revealed a mean survival time of 17±2.6 months. The cumulative two- and five-year survival rates were 34.8% and 7.8%, respectively. Univariate analysis showed that ≥60 age, left hemithorax involvement, a maximum standardized uptake value of ≥9.8, c-T4 status, c-M1 status, and non-surgery were negatively associated with overall survival (p<0.05). Multivariate analysis showed that ≥60 age, left hemithorax involvement, a maximum standardized uptake value of ≥9.8, c-M1 status, and a total lesion glycolysis of ≥180.2 g were negatively associated with overall survival (p<0.05).
Metabolic parameters of F-fluorodeoxyglucose positron emission tomography/computed tomography have the potential to provide prognostic information for malignant pleural mesothelioma patients who are receiving surgery and/or chemotherapy.
在本研究中，我们旨在探讨代谢型氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描参数对恶性胸膜间皮瘤患者的预后价值。
纳入2008年3月至2018年1月期间共65例接受全身氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描以进行治疗前分期的恶性胸膜间皮瘤患者（34例男性，31例女性；中位年龄：60岁；范围39至84岁）。使用对数秩检验和Cox回归分析评估临床病理因素与氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描参数及总生存期之间的关系。
中位随访时间为13（范围4至55）个月。Kaplan-Meier分析显示平均生存时间为17±2.6个月。累积两年和五年生存率分别为34.8%和7.8%。单因素分析显示年龄≥60岁、左侧胸腔受累、最大标准化摄取值≥9.8、c-T4状态、c-M1状态和未手术与总生存期呈负相关（p<0.05）。多因素分析显示年龄≥60岁、左侧胸腔受累、最大标准化摄取值≥9.8、c-M1状态和总病变糖酵解≥180.2 g与总生存期呈负相关（p<0.05）。
氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描的代谢参数有可能为接受手术和/或化疗的恶性胸膜间皮瘤患者提供预后信息。
