Ebinç Senar, Oruç Zeynep, Kalkan Ziya, Karhan Oğur, Urakçı Zuhat, Küçüköner Mehmet, Kaplan Muhammet Ali, Abdurrahman Işıkdoğan
Department of Internal Medicine, Division of Medical Oncology, Dicle University Faculty of Medicine, Diyarbakır, Türkiye.
Turk Gogus Kalp Damar Cerrahisi Derg. 2023 Jan 30;31(1):105-115. doi: 10.5606/tgkdc.dergisi.2023.23365. eCollection 2023 Jan.
In this study, we aimed to investigate the prognostic factors of malignant pleural mesothelioma and the prognostic value of inflammation indices in malignant pleural mesothelioma.
Between January 2002 and December 2019, a total of 132 patients (74 males, 58 females; mean age: 55 years; range, 31 to 79 years) diagnosed with malignant pleural mesothelioma were retrospectively analyzed. Patients" demographic data and laboratory results were recorded. The prognostic value of the following five inflammation indices was evaluated: neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, advanced lung cancer inflammation index, C-reactive protein/albumin ratio, and prognostic nutritional index.
Of all patients, 81% (n=107) were aged 65 or older and 61.4% (n=81) had an epithelioid histology. Of 12 variables examined in the multivariate analysis for their relationship with survival, age ≥65 years, non-epithelioid subtype, and prognostic nutritional index <40 were found to be poor prognostic factors. Based on the score constructed from these factors, the good prognostic group (score 0-1) had a median overall survival of 21 months and a one-year survival rate of 77.9%, while the poor prognostic group (score 2-3) had a median overall survival of nine months and a one-year survival rate of 29.7%.
Our study results indicate that age ≥65 years, prognostic nutritional index <40, and non-epithelioid histological subtype are poor prognostic factors of malignant pleural mesothelioma.
在本研究中，我们旨在探讨恶性胸膜间皮瘤的预后因素以及炎症指标在恶性胸膜间皮瘤中的预后价值。
回顾性分析2002年1月至2019年12月期间共132例诊断为恶性胸膜间皮瘤的患者（74例男性，58例女性；平均年龄：55岁；范围31至79岁）。记录患者的人口统计学数据和实验室结果。评估以下五个炎症指标的预后价值：中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值、晚期肺癌炎症指数、C反应蛋白/白蛋白比值和预后营养指数。
在所有患者中，81%（n = 107）年龄在65岁及以上，61.4%（n = 81）具有上皮样组织学类型。在多变量分析中检查的1与生存相关的2个变量中，年龄≥65岁、非上皮样亚型和预后营养指数<40被发现是不良预后因素。根据这些因素构建的评分，良好预后组（评分0 - 1）的中位总生存期为21个月，一年生存率为77.9%，而不良预后组（评分2 - 3）的中位总生存期为9个月，一年生存率为29.7%。
我们的研究结果表明，年龄≥65岁、预后营养指数<40和非上皮样组织学亚型是恶性胸膜间皮瘤的不良预后因素。
