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What makes a good fragment in fragment-based drug discovery?

作者信息

Konteatis Zenon

机构信息

Director, Chemistry Department, Agios Pharmaceuticals, Inc., Cambridge, Massachusetts, USA.

出版信息

Expert Opin Drug Discov. 2021 Jul;16(7):723-726. doi: 10.1080/17460441.2021.1905629. Epub 2021 Mar 26.

DOI:10.1080/17460441.2021.1905629
PMID:33769176
Abstract
摘要

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What makes a good fragment in fragment-based drug discovery?在基于片段的药物发现中,什么样的片段才是好的片段?
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Two 'Golden Ratio' indices in fragment-based drug discovery.基于片段的药物发现中的两个“黄金比例”指标。
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