鼠李半乳糖醛酸聚糖II：包含α-2,3-连接的Kdo的亚结构的化学合成*
Rhamnogalacturonan II: Chemical Synthesis of a Substructure Including α-2,3-Linked Kdo*.
作者信息
Mancuso Enzo, Romanò Cecilia, Trattnig Nino, Gritsch Philipp, Kosma Paul, Clausen Mads H
机构信息
Department of Chemistry, Center for Nanomedicine and Theranostics, Technical University of Denmark, Kemitorvet 207, 2800, Kgs., Lyngby, Denmark.
Department of Chemistry, University of Natural Resources and Life Sciences, 18 Muthgasse, 1190, Vienna, Austria.
出版信息
Chemistry. 2021 Apr 26;27(24):7099-7102. doi: 10.1002/chem.202100837. Epub 2021 Apr 9.
The synthesis of a fully deprotected Kdo-containing rhamnogalacturonan II pentasaccharide is described. The strategy relies on the preparation of a suitably protected homogalacturonan tetrasaccharide backbone, through a post-glycosylation oxidation approach, and its stereoselective glycosylation with a Kdo fluoride donor.
描述了一种完全脱保护的含Kdo的鼠李半乳糖醛酸聚糖II五糖的合成。该策略依赖于通过糖基化后氧化方法制备适当保护的同型半乳糖醛酸聚糖四糖骨架，以及用Kdo氟化物供体进行其立体选择性糖基化。
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