J Am Anim Hosp Assoc. 2021 May 1;57(3):114-120. doi: 10.5326/JAAHA-MS-7121.
The purpose of this study was to describe the clinical presentation, imaging findings, and outcome in 10 dogs diagnosed with Rhinosporidium seeberi infections. Histopathology and cytology records were searched at a veterinary teaching hospital and a veterinary diagnostic laboratory to identify dogs with rhinosporidiosis. Medical records were reviewed for clinical, imaging, endoscopic, and surgical findings. Outcome was determined via evaluation of records and, where possible, telephone conversation with the primary care veterinarian and/or owner. Young to middle-aged large-breed dogs with an approximately equal sex distribution were represented. Unilateral signs predominated. Diagnosis was confirmed by histopathology in 9 cases, and cytology was diagnostic in only 1 of 3 cases. Histopathology was superior to cytology. Masses were soft tissue and contrast enhancing with no evidence of bony lysis on computed tomography (2 dogs). Direct or rhinoscopic (2 dogs) visualization revealed white to yellow pinpoint foci. Surgical resection (4 dogs) can result in long-term disease-free periods (up to 2659 days), although repeat surgery can be required. Dapsone was well tolerated in 1 dog, and relapse was not noted despite incomplete surgical resection (follow-up 749 days). Visualization of pale foci on a rostral intranasal mass in an endemic region should prompt consideration of rhinosporidiosis.
本研究旨在描述 10 只诊断为 Rhinosporidium seeberi 感染的犬的临床症状、影像学表现和转归。在一家兽医教学医院和一家兽医诊断实验室，通过检索组织病理学和细胞学记录来确定患有鼻孢子虫病的犬。通过回顾病历，评估临床、影像学、内镜和手术发现。通过评估记录，以及在可能的情况下与初级保健兽医和/或主人进行电话交谈，确定了转归。代表了大约相等性别分布的年轻到中年大型犬。单侧症状占优势。9 例通过组织病理学确诊，3 例中仅 1 例细胞学诊断。组织病理学优于细胞学。CT 未见骨溶解的软组织肿块，增强扫描呈阳性（2 例）。直接或鼻镜检查（2 例）可见白色至黄色针尖状病灶。手术切除（4 例）可导致长期无疾病期（长达 2659 天），尽管可能需要重复手术。1 只犬对氨苯砜耐受良好，尽管不完全手术切除（随访 749 天），但未出现复发。在流行地区，在鼻腔肿块的鼻腔前段看到苍白病灶应提示考虑鼻孢子虫病。
