Kirkpatrick T, Henderson P D, Nimmo W S
Department of Anaesthetics, Royal Hallamshire Hospital, Sheffield.
Anaesthesia. 1988 Apr;43(4):293-5. doi: 10.1111/j.1365-2044.1988.tb08976.x.
The absorption of morphine 10 mg after intramuscular injection into the gluteal and deltoid muscles was investigated. Ten patients received the injection into the deltoid and 10 were given the injection into the upper outer quadrant of the buttock. Blood was taken at frequent intervals up to 2 hours after the injection for plasma morphine analysis by high performance liquid chromatography. Morphine concentrations were generally higher in the gluteal group although the mean peak concentrations (62.8 ng/ml in the gluteal group and 52.3 ng/ml in the deltoid group) were similar. Peak morphine concentrations varied from 22.5-99.3 ng/ml in the gluteal group and 26.5-84.5 ng/ml in the deltoid group. The area under the concentration-time curve was significantly greater in the gluteal group than in the deltoid group but this difference disappeared when allowance was made for differences in body weight of the two groups. We conclude that the absorption of morphine from the deltoid and gluteal sites is similar.
研究了肌肉注射10毫克吗啡后在三角肌和臀肌中的吸收情况。10名患者接受了三角肌注射，10名患者接受了臀部外上象限注射。在注射后长达2小时的时间内，每隔一段时间采集血液，通过高效液相色谱法分析血浆中的吗啡。臀肌组的吗啡浓度总体上较高，尽管平均峰值浓度（臀肌组为62.8纳克/毫升，三角肌组为52.3纳克/毫升）相似。臀肌组的吗啡峰值浓度在22.5 - 99.3纳克/毫升之间，三角肌组在26.5 - 84.5纳克/毫升之间。浓度 - 时间曲线下的面积在臀肌组明显大于三角肌组，但在考虑两组体重差异后，这种差异消失了。我们得出结论，吗啡从三角肌和臀肌部位的吸收情况相似。
