Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Bio-Medical Institute of Technology, University of Ulsan, College of Medicine, Ulsan, Korea.
J Am Acad Dermatol. 2022 Jun;86(6):1258-1265. doi: 10.1016/j.jaad.2021.03.056. Epub 2021 Mar 23.
The clinicoprognostic implications of head and neck involvement of mycosis fungoides (MF) are poorly understood.
To evaluate the association of head and neck involvement on the clinicoprognostic features of MF.
The clinical features and survival outcomes of patients with MF in a Korean academic medical center database were retrospectively evaluated according to the presence of head and neck involvement at diagnosis.
Cases of MF with (group A, n = 39) and without (group B, n = 85) head and neck involvement at diagnosis were identified. Advanced-stage disease (stages IIB-IVB) was more common in group A (43.6%) than in group B (5.9%) (P < .001). MF progression, extracutaneous dissemination, and large-cell transformation more commonly occurred in group A than in group B. The 10-year overall survival rate was worse in group A (53.4%) compared with group B (81.6%) (P < .001). Head and neck involvement at diagnosis was associated with poor prognosis in early-stage MF (stages IA-IIA) and was independently associated with worse progression-free survival (hazard ratio, 24.4; 95% confidence interval, 2.2-267.6; P = .009).
A single center, retrospective design.
Head and neck involvement of MF was associated with a poor prognosis.
蕈样肉芽肿（MF）头颈部受累的临床预后意义尚未明确。
评估 MF 头颈部受累与临床预后特征的相关性。
回顾性分析一家韩国学术医疗中心数据库中 MF 患者的临床特征和生存结局，根据诊断时是否存在头颈部受累进行分组。
共纳入诊断时存在（A 组，n=39）和不存在（B 组，n=85）头颈部受累的 MF 病例。A 组中晚期疾病（IIB-IVB 期）更为常见（43.6%），B 组则为少见（5.9%）（P<0.001）。A 组 MF 进展、皮肤外播散和大细胞转化更为常见。A 组 10 年总生存率（53.4%）低于 B 组（81.6%）（P<0.001）。诊断时存在头颈部受累与早期 MF（IA-IIA 期）的不良预后相关，且与无进展生存期更差独立相关（风险比，24.4；95%置信区间，2.2-267.6；P=0.009）。
单中心、回顾性设计。
MF 头颈部受累与预后不良相关。
