• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

关于使用包络跟随反应估计听觉系统外周水平压缩的研究。

On the use of envelope following responses to estimate peripheral level compression in the auditory system.

机构信息

Hearing Systems Section, Department of Health Technology, Technical University of Denmark (DTU), 2800, Kongens Lyngby, Denmark.

出版信息

Sci Rep. 2021 Mar 26;11(1):6962. doi: 10.1038/s41598-021-85850-x.

DOI:10.1038/s41598-021-85850-x
PMID:33772043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7997911/
Abstract

Individual estimates of cochlear compression may provide complementary information to traditional audiometric hearing thresholds in disentangling different types of peripheral cochlear damage. Here we investigated the use of the slope of envelope following response (EFR) magnitude-level functions obtained from four simultaneously presented amplitude modulated tones with modulation frequencies of 80-100 Hz as a proxy of peripheral level compression. Compression estimates in individual normal hearing (NH) listeners were consistent with previously reported group-averaged compression estimates based on psychoacoustical and distortion-product oto-acoustic emission (DPOAE) measures in human listeners. They were also similar to basilar membrane (BM) compression values measured invasively in non-human mammals. EFR-based compression estimates in hearing-impaired listeners were less compressive than those for the NH listeners, consistent with a reduction of BM compression. Cochlear compression was also estimated using DPOAEs in the same NH listeners. DPOAE estimates were larger (less compressive) than EFRs estimates, showing no correlation. Despite the numerical concordance between EFR-based compression estimates and group-averaged estimates from other methods, simulations using an auditory nerve (AN) model revealed that compression estimates based on EFRs might be highly influenced by contributions from off-characteristic frequency (CF) neural populations. This compromises the possibility to estimate on-CF (i.e., frequency-specific or "local") peripheral level compression with EFRs.

摘要

个体耳蜗压缩的估计可能会提供比传统听力阈值更多的补充信息，从而可以区分不同类型的外周耳蜗损伤。在这里，我们研究了使用四个同时呈现的幅度调制音调的包络跟随响应 (EFR) 幅度-电平函数的斜率作为外周水平压缩的替代指标。个体正常听力 (NH) 听众的压缩估计值与以前基于心理声学和失真产物耳声发射 (DPOAE) 测量的人类听众的组平均压缩估计值一致。它们也与在非人类哺乳动物中侵入性测量的基底膜 (BM) 压缩值相似。听力受损听众的 EFR 基压缩估计值不如 NH 听众的压缩估计值大，这与 BM 压缩减少一致。同样，在相同的 NH 听众中也使用 DPOAE 来估计耳蜗压缩。DPOAE 估计值比 EFR 估计值大（压缩性较小），没有相关性。尽管 EFR 基压缩估计值与其他方法的组平均估计值在数值上一致，但使用听神经 (AN) 模型进行的模拟表明，基于 EFR 的压缩估计值可能会受到特征频率 (CF) 以外的神经元群体的强烈影响。这限制了使用 EFR 来估计 CF 内（即频率特异性或“局部”）外周水平压缩的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/e6d8c0e0a8bc/41598_2021_85850_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/d75991eb4dab/41598_2021_85850_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/f59e33f8752c/41598_2021_85850_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/4e2e9d9333a7/41598_2021_85850_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/a6c4e03b8a42/41598_2021_85850_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/4bb383d0a019/41598_2021_85850_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/0fc7f33905f4/41598_2021_85850_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/e6d8c0e0a8bc/41598_2021_85850_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/d75991eb4dab/41598_2021_85850_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/f59e33f8752c/41598_2021_85850_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/4e2e9d9333a7/41598_2021_85850_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/a6c4e03b8a42/41598_2021_85850_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/4bb383d0a019/41598_2021_85850_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/0fc7f33905f4/41598_2021_85850_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/66ac/7997911/e6d8c0e0a8bc/41598_2021_85850_Fig7_HTML.jpg

相似文献

1
On the use of envelope following responses to estimate peripheral level compression in the auditory system.关于使用包络跟随反应估计听觉系统外周水平压缩的研究。
Sci Rep. 2021 Mar 26;11(1):6962. doi: 10.1038/s41598-021-85850-x.
2
Investigating the Effect of Cochlear Synaptopathy on Envelope Following Responses Using a Model of the Auditory Nerve.探讨耳蜗突触病对听神经模型包络跟随反应的影响。
J Assoc Res Otolaryngol. 2019 Aug;20(4):363-382. doi: 10.1007/s10162-019-00721-7. Epub 2019 May 17.
3
Sensitivity of envelope following responses to vowel polarity.元音极性的包络跟随反应的敏感性。
Hear Res. 2015 Feb;320:38-50. doi: 10.1016/j.heares.2014.11.008. Epub 2014 Dec 9.
4
Changes in the Compressive Nonlinearity of the Cochlea During Early Aging: Estimates From Distortion OAE Input/Output Functions.早期衰老过程中耳蜗压缩非线性的变化：基于畸变耳声发射输入/输出函数的估计
Ear Hear. 2016 Sep-Oct;37(5):603-14. doi: 10.1097/AUD.0000000000000319.
5
Cochlear compression in listeners with moderate sensorineural hearing loss.中度感音神经性听力损失患者的耳蜗压缩
Hear Res. 2005 Jul;205(1-2):172-83. doi: 10.1016/j.heares.2005.03.015.
6
Envelope following responses predict speech-in-noise performance in normal-hearing listeners.包络跟随反应可预测正常听力者在噪声中言语的表现。
J Neurophysiol. 2021 Apr 1;125(4):1213-1222. doi: 10.1152/jn.00620.2020. Epub 2021 Mar 3.
7
Behavioral estimates of basilar-membrane compression: additivity of forward masking in noise-masked normal-hearing listeners.行为估计基底膜的压缩：在噪声掩蔽的正常听力听众中前向掩蔽的可加性。
J Acoust Soc Am. 2011 Nov;130(5):2835-44. doi: 10.1121/1.3643817.
8
Cochlear compression estimates from measurements of distortion-product otoacoustic emissions.通过畸变产物耳声发射测量进行的耳蜗压缩估计
J Acoust Soc Am. 2003 Sep;114(3):1499-507. doi: 10.1121/1.1604122.
9
Assessing Cochlear-Place Specific Temporal Coding Using Multi-Band Complex Tones to Measure Envelope-Following Responses.使用多频带复合音评估耳蜗-部位特异性时间编码以测量包络追随反应。
Neuroscience. 2019 May 21;407:67-74. doi: 10.1016/j.neuroscience.2019.02.003. Epub 2019 Mar 1.
10
Compression estimates using behavioral and otoacoustic emission measures.使用行为学和耳声发射测量方法进行的压迫估计
Hear Res. 2005 Mar;201(1-2):44-54. doi: 10.1016/j.heares.2004.10.006.

引用本文的文献

1
Deciphering Compromised Speech-in-Noise Intelligibility in Older Listeners: The Role of Cochlear Synaptopathy.解读老年听众在噪声环境中言语清晰度受损的原因：耳蜗突触病变的作用。
eNeuro. 2025 Feb 20;12(2). doi: 10.1523/ENEURO.0182-24.2024. Print 2025 Feb.
2
Sensory representations and pupil-indexed listening effort provide complementary contributions to multi-talker speech intelligibility.感觉表征和瞳孔索引的听觉努力对多说话者语音可懂度有互补作用。
Sci Rep. 2024 Dec 28;14(1):30882. doi: 10.1038/s41598-024-81673-8.
3
Diagnosing awareness in disorders of consciousness with gamma-band auditory responses.

本文引用的文献

1
Biased auditory nerve central synaptopathy is associated with age-related hearing loss.听觉神经中枢突触病变与年龄相关性听力损失有关。
J Physiol. 2021 Mar;599(6):1833-1854. doi: 10.1113/JP281014. Epub 2021 Jan 31.
2
Age-Related Hearing Loss Is Dominated by Damage to Inner Ear Sensory Cells, Not the Cellular Battery That Powers Them.年龄相关性听力损失主要由内耳感觉细胞的损伤引起，而不是为其提供能量的细胞电池。
J Neurosci. 2020 Aug 12;40(33):6357-6366. doi: 10.1523/JNEUROSCI.0937-20.2020. Epub 2020 Jul 20.
3
The derived-band envelope following response and its sensitivity to sensorineural hearing deficits.
利用γ波段听觉反应诊断意识障碍中的意识状态
Front Hum Neurosci. 2024 Jan 5;17:1243051. doi: 10.3389/fnhum.2023.1243051. eCollection 2023.
4
Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study.增强平行听觉脑干反应的位置特异性：一项建模研究。
Trends Hear. 2023 Jan-Dec;27:23312165231205719. doi: 10.1177/23312165231205719.
5
Effects of age on electrophysiological measures of cochlear synaptopathy in humans.年龄对人类耳蜗突触病变电生理指标的影响。
Hear Res. 2020 Oct;396:108068. doi: 10.1016/j.heares.2020.108068. Epub 2020 Sep 8.
衍生频带包络跟随反应及其对感音神经性听力损失的敏感性。
Hear Res. 2020 Jul;392:107979. doi: 10.1016/j.heares.2020.107979. Epub 2020 Apr 29.
4
Investigating the Effect of Cochlear Synaptopathy on Envelope Following Responses Using a Model of the Auditory Nerve.探讨耳蜗突触病对听神经模型包络跟随反应的影响。
J Assoc Res Otolaryngol. 2019 Aug;20(4):363-382. doi: 10.1007/s10162-019-00721-7. Epub 2019 May 17.
5
Reliability and interrelations of seven proxy measures of cochlear synaptopathy.七种耳蜗突触病代理测量指标的可靠性和相互关系。
Hear Res. 2019 Apr;375:34-43. doi: 10.1016/j.heares.2019.01.018. Epub 2019 Jan 23.
6
Synaptopathy in the Aging Cochlea: Characterizing Early-Neural Deficits in Auditory Temporal Envelope Processing.衰老耳蜗中的突触病变：听觉时间包络处理的早期神经缺陷特征。
J Neurosci. 2018 Aug 8;38(32):7108-7119. doi: 10.1523/JNEUROSCI.3240-17.2018. Epub 2018 Jul 5.
7
Subcortical sources dominate the neuroelectric auditory frequency-following response to speech.皮层下来源主导言语神经电听觉频率跟随反应。
Neuroimage. 2018 Jul 15;175:56-69. doi: 10.1016/j.neuroimage.2018.03.060. Epub 2018 Mar 28.
8
A phenomenological model of the synapse between the inner hair cell and auditory nerve: Implications of limited neurotransmitter release sites.内毛细胞与听神经之间突触的现象学模型：神经递质释放位点有限的影响。
Hear Res. 2018 Mar;360:40-54. doi: 10.1016/j.heares.2017.12.016. Epub 2017 Dec 28.
9
Investigating time-efficiency of forward masking paradigms for estimating basilar membrane input-output characteristics.研究用于估计基底膜输入-输出特性的前掩蔽范式的时间效率。
PLoS One. 2017 Mar 29;12(3):e0174776. doi: 10.1371/journal.pone.0174776. eCollection 2017.
10
Cortical Correlates of the Auditory Frequency-Following and Onset Responses: EEG and fMRI Evidence.听觉频率跟随与起始反应的皮质相关性：脑电图和功能磁共振成像证据
J Neurosci. 2017 Jan 25;37(4):830-838. doi: 10.1523/JNEUROSCI.1265-16.2016.