Psychosis Research Unit, Aarhus University Hospital-Psychiatry, Palle Juul-Jensens Boulevard 175, 8200 Aarhus N, Denmark.
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus University, Aarhus, Denmark.
Schizophr Bull. 2021 Aug 21;47(5):1342-1350. doi: 10.1093/schbul/sbab021.
Nonrandom mating in parents with schizophrenia or bipolar disorder increases the population-level genetic variance among the offspring generation and creates familial (risk) environments likely to be shaped by specific conditions. The objective of this study was to investigate the occurrence of mental disorder and levels of cognitive and social functioning in individuals who have children by partners with schizophrenia or bipolar disorder compared to controls. The Danish High Risk and Resilience Study VIA 7 is a population-based cohort study conducted in Denmark between 2013 and 2016. This study focus on parents diagnosed with schizophrenia (n = 150) or bipolar disorder (n = 100) and control parents (n = 182), as well as their partners without schizophrenia or bipolar disorder (n = 440). We used linear mixed-effect models, and main outcomes were mental disorders, intelligence, processing speed, verbal working memory, and social functioning. We found that parents having children by a partner with schizophrenia or bipolar disorder more often fulfilled the criteria for a mental disorder and had poorer social functioning compared to parents having children by a partner without schizophrenia or bipolar disorder. Furthermore, parents having children by a partner with schizophrenia performed poorer on processing speed compared to parents in the control group. The presence of nonrandom mating found in this study has implications for our understanding of familial transmission of these disorders and our findings should be considered in future investigations of potential risk factors for children with a parent with schizophrenia or bipolar disorder.
非随机交配在患有精神分裂症或双相情感障碍的父母中增加了后代群体的人群遗传方差，并创造了可能由特定条件塑造的家族（风险）环境。本研究的目的是调查与对照组相比，与患有精神分裂症或双相情感障碍的伴侣生育子女的个体的精神障碍发生情况和认知及社会功能水平。丹麦高危和弹性研究 VIA 7 是一项在丹麦于 2013 年至 2016 年期间开展的基于人群的队列研究。本研究重点关注患有精神分裂症的父母（n=150）或双相情感障碍的父母（n=100）和对照组父母（n=182），以及他们没有精神分裂症或双相情感障碍的伴侣（n=440）。我们使用线性混合效应模型，主要结局是精神障碍、智力、加工速度、言语工作记忆和社会功能。我们发现，与伴侣没有精神分裂症或双相情感障碍的父母相比，与患有精神分裂症或双相情感障碍的伴侣生育子女的父母更常符合精神障碍的标准，社会功能更差。此外，与对照组的父母相比，与患有精神分裂症的伴侣生育子女的父母在加工速度方面表现更差。本研究中发现的非随机交配的存在，对我们理解这些障碍的家族传递具有重要意义，我们的研究结果应在未来对患有精神分裂症或双相情感障碍父母的子女的潜在风险因素的研究中加以考虑。
