Institut de Neurosciences Intégratives et Cognitives d'Aquitaine, UMR 5287, CNRS, Université de Bordeaux, Bordeaux, France.
Sommeil, Addiction et Neuropsychiatrie, Université de Bordeaux, USR 3413, F-33000 Bordeaux, France.
Sleep. 2021 Sep 13;44(9). doi: 10.1093/sleep/zsab081.
Emotional reactivity to negative stimuli has been investigated in insomnia, but little is known about emotional reactivity to positive stimuli and its neural representation.
We used 3 Tesla functional magnetic resonance imaging (fMRI) to determine neural reactivity during the presentation of standardized short, 10- to 40-seconds, humorous films in patients with insomnia (n = 20, 18 females, aged 27.7 +/- 8.6 years) and age-matched individuals without insomnia (n = 20, 19 females, aged 26.7 +/- 7.0 years) and assessed humor ratings through a visual analog scale. Seed-based functional connectivity was analyzed for the left and right amygdalas (lAMYG and rAMYG, respectively) networks: group-level mixed-effects analysis (FLAME; FMRIB Software Library [FSL]) was used to compare amygdala connectivity maps between groups.
fMRI seed-based analysis of the amygdala revealed stronger neural reactivity in patients with insomnia than in controls in several brain network clusters within the reward brain network, without humor rating differences between groups (p = 0.6). For lAMYG connectivity, cluster maxima were in the left caudate (Z = 3.88), left putamen (Z = 3.79), and left anterior cingulate gyrus (Z = 4.11), whereas for rAMYG connectivity, cluster maxima were in the left caudate (Z = 4.05), right insula (Z = 3.83), and left anterior cingulate gyrus (Z = 4.29). Cluster maxima of the rAMYG network were correlated with hyperarousal scores in patients with insomnia only.
The presentation of humorous films leads to increased brain activity in the neural reward network for patients with insomnia compared with controls, related to hyperarousal features in patients with insomnia, in the absence of humor rating group differences. These novel findings may benefit insomnia treatment interventions.
The Sleepless Brain: Neuroimaging Support for a Differential Diagnosis of Insomnia (SOMNET). ClinicalTrials.gov identifier: NCT02821234; https://clinicaltrials.gov/ct2/show/NCT02821234.
已有研究调查了失眠症患者对负性刺激的情绪反应，但对正性刺激的情绪反应及其神经表现知之甚少。
我们使用 3 特斯拉功能磁共振成像（fMRI），在失眠症患者（n=20，18 名女性，年龄 27.7±8.6 岁）和年龄匹配的非失眠症个体（n=20，19 名女性，年龄 26.7±7.0 岁）呈现标准化的、10-40 秒的幽默短片时，确定神经反应。通过视觉模拟量表评估幽默评分。采用左、右杏仁核（lAMYG 和 rAMYG）网络的种子功能连接分析：采用组水平混合效应分析（FLAME；FMRIB 软件库[FSL]）比较组间杏仁核连接图。
杏仁核基于种子的 fMRI 分析显示，与对照组相比，失眠症患者在奖赏脑网络内的几个脑网络簇中表现出更强的神经反应，而两组之间的幽默评分无差异（p=0.6）。对于 lAMYG 连接，簇最大值位于左侧尾状核（Z=3.88）、左侧壳核（Z=3.79）和左侧前扣带回皮质（Z=4.11），而对于 rAMYG 连接，簇最大值位于左侧尾状核（Z=4.05）、右侧岛叶（Z=3.83）和左侧前扣带回皮质（Z=4.29）。rAMYG 网络的簇最大值仅与失眠症患者的觉醒过度评分相关。
与对照组相比，呈现幽默电影会导致失眠症患者的神经奖赏网络活动增加，与失眠症患者的觉醒过度特征有关，而两组之间的幽默评分无差异。这些新发现可能有益于失眠症的治疗干预。
失眠症的无眠大脑：神经影像学支持鉴别诊断（SOMNET）。ClinicalTrials.gov 标识符：NCT02821234；https://clinicaltrials.gov/ct2/show/NCT02821234。
