Cortactin 和 HS1 基因表达的评估：成人性 B 细胞急性淋巴细胞白血病的新角色。
Evaluation of Cortactin and HS1 Genes Expression: New Players in Adult B-Cell Acute Lymphoblastic leukemia.
机构信息
Hematology Unit, Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Egypt.
Medical Oncology Unit, Mansoura University Oncology Center (MUOC) Mansoura University, Egypt.
出版信息
Asian Pac J Cancer Prev. 2021 Mar 1;22(3):767-774. doi: 10.31557/APJCP.2021.22.3.767.
OBJECTIVES
This study aimed to assess the prognostic value of cortactin and HS1 genes expression in adult B-cell acute lymphoblastic leukemia.
METHODS
The study included a cohort of 74 adult B-ALL patients and 76 controls. Cortactin and HS1 genes expression were quantified by real time PCR.
RESULTS
The expression of cortactin and HS1 were significantly higher in B-ALL patients at diagnosis as compared to post induction levels (p.
目的
本研究旨在评估 cortactin 和 HS1 基因表达在成人 B 细胞急性淋巴细胞白血病中的预后价值。
方法
本研究纳入了 74 例成人 B-ALL 患者和 76 例对照。通过实时 PCR 定量检测 cortactin 和 HS1 基因的表达。
结果
与诱导后水平相比，B-ALL 患者初诊时 cortactin 和 HS1 的表达显著升高（p.
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