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Hair Follicle Chemosensation: TRPM5 Signaling Is Required for Anagen Maintenance.

作者信息

Mardaryev Andrei, van Lessen Max, Alam Majid, Jimenez Acosta Francisco, Bíró Tamás, Paus Ralf

机构信息

Centre for Skin Sciences, School of Chemistry and Biosciences, University of Bradford, Bradford, United Kingdom.

Monasterium Laboratory - Skin and Hair Research Solutions GmbH, Münster, Germany.

出版信息

J Invest Dermatol. 2021 Sep;141(9):2300-2303. doi: 10.1016/j.jid.2021.02.747. Epub 2021 Mar 24.

DOI:10.1016/j.jid.2021.02.747
PMID:33773986
Abstract
摘要

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The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5-Independent Manner.TRPM5拮抗剂三苯基氧化膦以不依赖TRPM5的方式增加皮脂腺脂质生成并调节人皮脂腺细胞的免疫表型。
Exp Dermatol. 2025 May;34(5):e70115. doi: 10.1111/exd.70115.
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The TRP channels serving as chemical-to-electrical signal converter.瞬时受体电位（TRP）通道作为化学信号到电信号的转换器。
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"ThermoTRP" Channel Expression in Cancers: Implications for Diagnosis and Prognosis (Practical Approach by a Pathologist).
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mTORC1 activity negatively regulates human hair follicle growth and pigmentation.mTORC1 活性负调控人类毛囊生长和色素形成。
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