Meador K J, Loring D W, King D W, Gallagher B B, Rogers O L, Smith J R, Flanigin H F
Department of Neurology, Medical College of Georgia, Augusta 30912.
Ann Neurol. 1988 Feb;23(2):145-51. doi: 10.1002/ana.410230207.
Limbic evoked potentials were recorded from intracerebral electrodes bilaterally implanted in the hippocampi of 16 epileptic patients undergoing evaluation for surgical resection of a seizure focus. Spectral analysis of the limbic evoked potentials revealed consistently lower spectral power of both low-band (1-12.6 Hz) and high-band (13-20 Hz) components recorded form the hippocampus that was associated with the electrographically confirmed seizure focus as compared to the contralateral side. Limbic evoked potential recordings appear to be useful in the determination of a focal functional deficit and thus in identifying the site of epileptogenic pathology. Further, the results support the hypothesis of a local generator for limbic evoked potentials and demonstrate that limbic evoked potentials in humans include not only low-frequency, high-amplitude electric field changes, but also a high-frequency component.
对16例因癫痫病灶手术切除接受评估的癫痫患者双侧海马植入脑内电极记录边缘叶诱发电位。边缘叶诱发电位的频谱分析显示，与对侧相比，从与脑电图证实的癫痫病灶相关的海马记录到的低频（1-12.6Hz）和高频（13-20Hz）成分的频谱功率持续较低。边缘叶诱发电位记录似乎有助于确定局灶性功能缺陷，从而识别致痫病理部位。此外，结果支持边缘叶诱发电位局部发生器的假说，并证明人类边缘叶诱发电位不仅包括低频、高振幅电场变化，还包括高频成分。
