School of Psychology, University of Ottawa, Ottawa, Ontario, Canada; Bruyère Research Institute, Ottawa, Ontario, Canada.
School of Psychology, University of Ottawa, Ottawa, Ontario, Canada; Bruyère Research Institute, Ottawa, Ontario, Canada.
Neurobiol Aging. 2021 Jul;103:12-21. doi: 10.1016/j.neurobiolaging.2021.02.014. Epub 2021 Feb 26.
The occurrence of a very infrequent and unattended auditory stimulus is highly salient and may result in an interruption of the frontoparietal network controlling processing priorities. Research has suggested that older adults may be unable to compute the level of salience of unattended stimulus inputs. A multi-channel EEG was recorded in 20 younger adults and 20 older adults. In different conditions, a single 80 dB SPL auditory stimulus was presented relatively rapidly, every 1.5 s or very slowly, every 12.0 s. Participants ignored the auditory stimuli while watching a silent video. When the stimuli were presented rapidly, group differences were not observed for the amplitudes of N1 and P2, which peaked at 100 and 180 ms respectively. When stimuli were presented very slowly, their amplitudes were much enhanced for younger adults, but did not increase for older adults. The failure to observe a large increase in the amplitude of N1 and P2 in older adults for very slowly presented auditory stimuli provides strong evidence of a dysfunction of the salience network in this group.
非常罕见且未被注意到的听觉刺激的出现具有高度显著性，可能会导致控制处理优先级的额顶网络中断。研究表明，老年人可能无法计算未被注意到的刺激输入的显著性水平。对 20 名年轻成年人和 20 名老年成年人进行了多通道 EEG 记录。在不同的条件下，以相对较快的速度（每 1.5 秒一次）或非常缓慢的速度（每 12.0 秒一次）呈现单个 80 dB SPL 的听觉刺激。参与者在观看无声视频时忽略了听觉刺激。当刺激快速呈现时，N1 和 P2 的幅度在组间没有差异，它们分别在 100 和 180 毫秒处达到峰值。当刺激非常缓慢呈现时，年轻人的幅度大大增强，但老年人的幅度没有增加。对于非常缓慢呈现的听觉刺激，老年人的 N1 和 P2 幅度没有明显增加，这为该组突显网络功能障碍提供了有力证据。
