Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Department of Pathology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
J Dermatol. 2021 Jul;48(7):1086-1089. doi: 10.1111/1346-8138.15857. Epub 2021 Mar 27.
Indeterminate cell histiocytosis (ICH) and Langerhans cell histiocytosis (LCH) are rare histiocyte proliferating disorders with unknown etiologies. However, both tumor cells immunophenotypically share some features of Langerhans cells (LC), thereby expressing CD1a. Recent transcriptome analysis revealed that circulating CD1c myeloid dendritic cells are the potential precursor of LCH tumor cells. LC express CD1a as well as CD1c, but not CD1b. We discovered that both tumor cells express CD1c, but not CD1b, similar to LC. Moreover, like LC, both tumor cells express colony-stimulating factor 1 receptor (CSF-1R). Considering the crucial role of the interleukin (IL)-34/CSF-1R axis for the development and survival of LC, CSF-1R on both tumor cells might facilitate their survival and proliferation in situ. These data provide additional evidence to support the fact that ICH and LCH share immunophenotypical features with LC. In addition, we hypothesized that tumor cells in ICH and LCH survive and proliferate through IL-34-mediated CSF-1R signaling.
未确定细胞组织细胞增生症（ICH）和朗格汉斯细胞组织细胞增生症（LCH）是罕见的组织细胞增生性疾病，其病因不明。然而，两种肿瘤细胞的免疫表型都具有朗格汉斯细胞（LC）的某些特征，从而表达 CD1a。最近的转录组分析表明，循环 CD1c 髓样树突状细胞可能是 LCH 肿瘤细胞的潜在前体细胞。LC 表达 CD1a 和 CD1c，但不表达 CD1b。我们发现两种肿瘤细胞均表达 CD1c，但不表达 CD1b，与 LC 相似。此外，与 LC 一样，两种肿瘤细胞均表达集落刺激因子 1 受体（CSF-1R）。鉴于白细胞介素（IL）-34/CSF-1R 轴对 LC 发育和存活的关键作用，两种肿瘤细胞上的 CSF-1R 可能有助于它们在原位的存活和增殖。这些数据提供了额外的证据支持 ICH 和 LCH 与 LC 具有免疫表型特征的事实。此外，我们假设 ICH 和 LCH 中的肿瘤细胞通过 IL-34 介导的 CSF-1R 信号存活和增殖。
