Department of Pathology. Central Park Medical College, Lahore.
Department of biochemistry and Chemical pathology. Sheikh Zayed Hospital Lahore.
J Ayub Med Coll Abbottabad. 2021 Jan-Mar;33(1):9-13.
The most common complication of SLE is lupus nephritis (LN) causing high morbidity and mortality. The routine biomarkers used for the diagnosis of LN do not have the ability to predict the worsening in renal disease activity. Thus, there is need of a new biomarker leading to detection of flare in LN. The objective of this study was to assess the role of urinary neutrophil gelatinase associated lipocalin (uNGAL) as a predictor of renal flare in patients with lupus nephritis.
Including a total of 84 subjects, 42 cases were lupus patients without renal involvement and 42 cases were lupus patients with nephritis (24 active nephritis and 18 inactive nephritis). The diagnosis of lupus nephritis was established on the basis of renal biopsy. uNGAL was estimated in both groups.
This study revealed that the nephritis group had increased levels of uNGAL as compared to systemic erythematosus patients without having lupus nephritis (p-value <0.05). Patients with active nephritis had increased uNGAL levels as compared to patients with inactive nephritis.
From the findings in our study, it can be stated that uNGAL can prove to be a noninvasive, reliable and sensitive biomarker to predict flare in cases of lupus nephritis.
SLE 最常见的并发症是狼疮性肾炎（LN），导致高发病率和死亡率。用于诊断 LN 的常规生物标志物没有预测肾脏疾病活动恶化的能力。因此，需要一种新的生物标志物来检测 LN 的发作。本研究的目的是评估尿中性粒细胞明胶酶相关脂质运载蛋白（uNGAL）作为狼疮性肾炎患者肾脏发作预测因子的作用。
共纳入 84 例受试者，42 例为无肾受累的狼疮患者，42 例为狼疮肾炎患者（24 例活动期肾炎，18 例非活动期肾炎）。狼疮肾炎的诊断基于肾活检。在两组中均估计 uNGAL。
本研究表明，与无狼疮性肾炎的系统性红斑狼疮患者相比，肾炎组的 uNGAL 水平升高（p 值<0.05）。与非活动性肾炎患者相比，活动性肾炎患者的 uNGAL 水平升高。
根据我们的研究结果，可以说 uNGAL 可以作为一种非侵入性、可靠和敏感的生物标志物，预测狼疮性肾炎的发作。
